ECT2 and MT2A

Number of citations of the paper that reports this interaction (PMID 22990118)
7

Data Source:
BioGRID (two hybrid, affinity chromatography technology)

		ECT2	MT2A
Gene Name		epithelial cell transforming 2	metallothionein 2A
Image
Gene Ontology Annotations	Cellular Component	Nucleus Cytoplasm Cytosol Cell-cell Junction Tight Junction Midbody Nuclear Membrane Cleavage Furrow Intracellular Membrane-bounded Organelle Mitotic Spindle Centralspindlin Complex	Nucleus Cytoplasm Cytosol Perinuclear Region Of Cytoplasm
	Molecular Function	Signal Transducer Activity Rho Guanyl-nucleotide Exchange Factor Activity GTPase Activator Activity Protein Binding Rho GTPase Binding Protein Homodimerization Activity	Protein Binding Drug Binding Zinc Ion Binding
	Biological Process	Cell Morphogenesis Cytokinesis Small GTPase Mediated Signal Transduction Protein Transport Activation Of Protein Kinase Activity Positive Regulation Of Rho GTPase Activity Positive Regulation Of Cytokinesis Activation Of Rho GTPase Activity Activation Of Rac GTPase Activity Positive Regulation Of Protein Import Into Nucleus Positive Regulation Of Apoptotic Process Positive Regulation Of Cdc42 GTPase Activity Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Positive Regulation Of Neuron Differentiation Regulation Of Protein Kinase Activity Neurotrophin TRK Receptor Signaling Pathway Regulation Of Small GTPase Mediated Signal Transduction Protein Homooligomerization Regulation Of Attachment Of Spindle Microtubules To Kinetochore Cellular Response To Hydrogen Peroxide Tight Junction Assembly Cellular Response To Calcium Ion Cellular Response To Ionizing Radiation Apoptotic Signaling Pathway	Cellular Copper Ion Homeostasis Cytokine-mediated Signaling Pathway Cellular Response To Drug Cellular Response To Interleukin-3 Cellular Response To Erythropoietin Negative Regulation Of Growth Interferon-gamma-mediated Signaling Pathway Cellular Response To Zinc Ion
Pathways		Rho GTPase cycle Signaling by GPCR GPCR downstream signaling Signalling by NGF Cell death signalling via NRAGE, NRIF and NADE Signaling by Rho GTPases NRAGE signals death through JNK G alpha (12/13) signalling events p75 NTR receptor-mediated signalling	Interferon gamma signaling Interferon Signaling Cytokine Signaling in Immune system
Drugs
Diseases
GWAS		Obesity-related traits ( 23251661)
Protein-Protein Interactions		37 interactors: ABR C2orf42 CCDC91 CD19 CDK1 CHST10 COX2 CRIPAK CSTB EIF4A2 EIF5B ERAL1 F2RL2 FANCM GGN ILVBL KLHL20 MBD1 MT2A NOMO1 NPC2 OOSP2 OTUB1 PARD6A PCOLCE PLK1 POMP PSMA6 RACGAP1 RHOG RPS20 SNRNP200 SPATA22 TCEB1 THAP11 UBB VDAC2	13 interactors: ADAMTS4 ASS1 BARD1 CXorf40A DHODH ECT2 JMJD1C PAXIP1 PRKD1 RCHY1 SHBG SPINK7 USP25
Entrez ID		1894	4502
HPRD ID		11860	08863
Ensembl ID		ENSG00000114346
Uniprot IDs		G5E9L8 Q9H8V3	P02795
PDB IDs		3L46	1MHU 2MHU
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Ubiquitin-protein Ligase Activity Involved In Regulation Of Mitotic Cell Cycle Transition Regulation Of Ubiquitin-protein Ligase Activity Involved In Mitotic Cell Cycle Anaphase-promoting Complex-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Ubiquitin-protein Transferase Activity Positive Regulation Of Ligase Activity Positive Regulation Of Protein Ubiquitination Involved In Ubiquitin-dependent Protein Catabolic Process Regulation Of Ubiquitin-protein Transferase Activity Regulation Of Protein Ubiquitination Involved In Ubiquitin-dependent Protein Catabolic Process Regulation Of Protein Ubiquitination Cellular Macromolecule Catabolic Process Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Proteasomal Protein Catabolic Process Positive Regulation Of Protein Ubiquitination Positive Regulation Of Cell Cycle Positive Regulation Of Proteolysis Involved In Cellular Protein Catabolic Process Positive Regulation Of Proteolysis Negative Regulation Of Transferase Activity Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Cellular Protein Catabolic Process DNA Damage Checkpoint Modification-dependent Protein Catabolic Process Mitotic Cell Cycle Checkpoint Proteolysis Involved In Cellular Protein Catabolic Process Viral Process Cellular Protein Catabolic Process Response To Stress Cellular Response To DNA Damage Stimulus Regulation Of Apoptotic Process Protein Catabolic Process Cellular Response To Stress Neurotrophin TRK Receptor Signaling Pathway Regulation Of Cell Death Positive Regulation Of Protein Catabolic Process Negative Regulation Of Mitotic Cell Cycle Positive Regulation Of Cell Cycle Process Neurotrophin Signaling Pathway Regulation Of Cell Cycle Regulation Of Cellular Protein Metabolic Process Cell Cycle Checkpoint Regulation Of Proteolysis Regulation Of Catalytic Activity Mitotic DNA Damage Checkpoint Cellular Response To Hypoxia Cellular Response To Decreased Oxygen Levels Mitotic DNA Integrity Checkpoint Negative Regulation Of Cell Cycle Negative Regulation Of Protein Ubiquitination Mitotic Cell Cycle Phase Transition Cell Cycle Cell Cycle Phase Transition	Regulation Of Protein Metabolic Process Response To Stress Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Protein Metabolic Process Argininosuccinate Metabolic Process Positive Regulation Of Histone H3-K36 Methylation Primary Spermatocyte Growth Cellular Response To Stress Positive Regulation Of Histone Modification Positive Regulation Of Protein Modification Process Regulation Of Organelle Organization Regulation Of Protein Catabolic Process Protein Kinase D Signaling Negative Regulation Of MRNA 3'-end Processing Cellular Response To Amine Stimulus Response To Mycotoxin Positive Regulation Of Histone Deacetylase Activity 'de Novo' UMP Biosynthetic Process Positive Regulation Of Cellular Protein Metabolic Process Regulation Of Histone Modification Positive Regulation Of Endothelial Cell Chemotaxis By VEGF-activated Vascular Endothelial Growth Factor Receptor Signaling Pathway Positive Regulation Of Protein Ubiquitination Response To Ionizing Radiation Regulation Of Metabolic Process Positive Regulation Of Cell Migration By Vascular Endothelial Growth Factor Signaling Pathway Regulation Of Histone Deacetylase Activity Positive Regulation Of Apoptotic Process Positive Regulation Of Programmed Cell Death Positive Regulation Of Deacetylase Activity Positive Regulation Of Cell Death 'de Novo' Pyrimidine Nucleobase Biosynthetic Process Negative Regulation Of Protein Export From Nucleus Response To Purine-containing Compound Positive Regulation Of Metabolic Process Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Aspartate Metabolic Process Arginine Biosynthetic Process Protein K6-linked Ubiquitination Cellular Response To Laminar Fluid Shear Stress Cellular Response To Oleic Acid Regulation Of Proteolysis Regulation Of Proteasomal Protein Catabolic Process Chorion Development Positive Regulation Of Endothelial Cell Chemotaxis Cellular Response To Oxidative Stress Anatomical Structure Development Regulation Of Protein Ubiquitination Regulation Of Chromosome Organization Regulation Of Nucleocytoplasmic Transport Diaphragm Development
Tagcloud ?		broader correlate correlates cytoskeleton dbl dbs deregulated encodes exchange family gtpases guanine jun lfc lsc mpk2 nh2 oncogenes panel possess rho sets specificities structurally transformed transforming utilization versions weakly	22rv1 bax beclin cflar cisplatin consequently create hif1alpha ic50 ions kappab1 kras mt1a mtt participate pc pnt1a prostatic regard resistance short summary survivin term tumorous verified zinc zip1 znt
Tagcloud (Difference) ?		broader correlate correlates cytoskeleton dbl dbs deregulated encodes exchange family gtpases guanine jun lfc lsc mpk2 nh2 oncogenes panel possess rho sets specificities structurally transformed transforming utilization versions weakly	22rv1 bax beclin cflar cisplatin consequently create hif1alpha ic50 ions kappab1 kras mt1a mtt participate pc pnt1a prostatic regard resistance short summary survivin term tumorous verified zinc zip1 znt
Tagcloud (Intersection) ?