DSCAM and PAK1

Number of citations of the paper that reports this interaction (PMID 15169762)
13

Data Source:
HPRD (in vitro, in vivo)

		DSCAM	PAK1
Gene Name		Down syndrome cell adhesion molecule	p21 protein (Cdc42/Rac)-activated kinase 1
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Extracellular Region Plasma Membrane Integral Component Of Plasma Membrane Membrane Axon Growth Cone	Ruffle Cytoplasm Golgi Apparatus Cytosol Plasma Membrane Cell-cell Junction Focal Adhesion Intercalated Disc Z Disc Axon Dendrite Growth Cone Filamentous Actin Nuclear Membrane Ruffle Membrane Protein Complex
	Molecular Function	Protein Binding	Protein Kinase Activity Protein Serine/threonine Kinase Activity Receptor Signaling Protein Serine/threonine Kinase Activity Protein Binding Collagen Binding ATP Binding Protein Kinase Binding
	Biological Process	Cell Adhesion Negative Regulation Of Cell Adhesion Nervous System Development Locomotory Behavior Positive Regulation Of Phosphorylation Dendrite Morphogenesis Positive Regulation Of Axon Extension Involved In Axon Guidance Post-embryonic Retina Morphogenesis In Camera-type Eye Dendrite Self-avoidance	MAPK Cascade Mitotic Cell Cycle Response To Hypoxia Positive Regulation Of Protein Phosphorylation Protein Phosphorylation Exocytosis Apoptotic Process Axon Guidance Neuromuscular Junction Development Dendrite Development Signal Transduction By Phosphorylation T Cell Costimulation Actin Cytoskeleton Reorganization Cellular Response To Insulin Stimulus Positive Regulation Of Peptidyl-serine Phosphorylation Positive Regulation Of Intracellular Estrogen Receptor Signaling Pathway Fc-epsilon Receptor Signaling Pathway Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Wound Healing Receptor Clustering Positive Regulation Of JUN Kinase Activity Innate Immune Response Protein Autophosphorylation Vascular Endothelial Growth Factor Receptor Signaling Pathway Ephrin Receptor Signaling Pathway Branching Morphogenesis Of An Epithelial Tube Neuron Projection Morphogenesis T Cell Receptor Signaling Pathway Positive Regulation Of Stress Fiber Assembly Negative Regulation Of Cell Proliferation Involved In Contact Inhibition
Pathways		DSCAM interactions	Axon guidance Costimulation by the CD28 family FCERI mediated MAPK activation L1CAM interactions VEGFA-VEGFR2 Pathway EPHB-mediated forward signaling Ephrin signaling Activation of Rac VEGFR2 mediated vascular permeability EPH-Ephrin signaling Fcgamma receptor (FCGR) dependent phagocytosis Regulation of actin dynamics for phagocytic cup formation Innate Immune System Generation of second messenger molecules Signal transduction by L1 Semaphorin interactions CD28 co-stimulation CD28 dependent Vav1 pathway TCR signaling DSCAM interactions Signaling by VEGF Sema3A PAK dependent Axon repulsion Fc epsilon receptor (FCERI) signaling Signaling by Robo receptor Adaptive Immune System
Drugs
Diseases
GWAS		Neutrophil count ( 21507922) Non-small cell lung cancer ( 21079520) Obesity-related traits ( 23251661)
Protein-Protein Interactions		1 interactors: PAK1	83 interactors: ABI3 ACTA1 ACVR1 AKT1 APP ARHGEF2 ARHGEF6 ARHGEF7 ARPC1B BAD BAIAP2 BMPR1B BMX BRSK1 C5orf42 CASP1 CDC42 CDK11B CDK5 CDK5R1 CHORDC1 COL1A1 CRIPAK CSNK2A1 CSNK2A2 DSCAM DYNLL1 DYNLL2 DYRK1B EGFR ELF3 ERBB2 ESR1 FLNA FOXL2 FOXO1 FRS2 GIT2 GRB2 HGS HIST1H3A HIST1H4A HSP90AA1 LIMK1 MAP2K1 MAP3K1 MAPK1 MBP MYLK MYNN MYO6 NCK1 NCK2 NF2 OXSR1 PAK1IP1 PDPK1 PLCG1 PPM1F PRKCD PXN RAC1 RAF1 RHOJ RHOU SHC1 SMAD1 SMAD2 SMAD4 SMURF1 SORBS2 SORBS3 SYN1 TGFBR1 TGFBR2 TGM2 YWHAG YWHAZ ZBTB18 ZC3H7A ZNF418 ZNF823 ZNF83
Entrez ID		1826	5058
HPRD ID		03953	03995
Ensembl ID		ENSG00000171587	ENSG00000149269
Uniprot IDs		O60469 Q8WY19	B3KNX7 Q13153
PDB IDs			1F3M 1YHV 1YHW 1ZSG 2HY8 2QME 3DVP 3FXZ 3FY0 3Q4Z 3Q52 3Q53 4DAW 4EQC
Enriched GO Terms of Interacting Partners?		Negative Regulation Of Cell Proliferation Involved In Contact Inhibition Positive Regulation Of Intracellular Estrogen Receptor Signaling Pathway Histone H3-T11 Phosphorylation Contact Inhibition Positive Regulation Of Intracellular Steroid Hormone Receptor Signaling Pathway Regulation Of Intracellular Estrogen Receptor Signaling Pathway Hyperosmotic Response Activation Of JUN Kinase Activity Histone Phosphorylation Positive Regulation Of Stress Fiber Assembly Peptidyl-threonine Phosphorylation Receptor Clustering Neuromuscular Junction Development Positive Regulation Of Actin Filament Bundle Assembly Regulation Of Intracellular Steroid Hormone Receptor Signaling Pathway Regulation Of Stress Fiber Assembly Actin Cytoskeleton Reorganization Positive Regulation Of JUN Kinase Activity T Cell Costimulation Positive Regulation Of Peptidyl-serine Phosphorylation Regulation Of JUN Kinase Activity JNK Cascade Response To Osmotic Stress Ephrin Receptor Signaling Pathway Epithelial Cell Migration Vascular Endothelial Growth Factor Receptor Signaling Pathway Epithelium Migration Regulation Of Peptidyl-serine Phosphorylation T Cell Receptor Signaling Pathway Stress-activated MAPK Cascade Stress-activated Protein Kinase Signaling Cascade Positive Regulation Of JNK Cascade Positive Regulation Of Stress-activated MAPK Cascade Positive Regulation Of Stress-activated Protein Kinase Signaling Cascade Dendrite Development Antigen Receptor-mediated Signaling Pathway Activation Of MAPK Activity Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Fc-gamma Receptor Signaling Pathway Fc Receptor Mediated Stimulatory Signaling Pathway Regulation Of JNK Cascade Synapse Organization Ameboidal-type Cell Migration Regulation Of Stress-activated MAPK Cascade Positive Regulation Of Cytoskeleton Organization Branching Morphogenesis Of An Epithelial Tube Protein Autophosphorylation Cellular Response To Insulin Stimulus Positive Regulation Of T Cell Activation Positive Regulation Of MAP Kinase Activity	Enzyme Linked Receptor Protein Signaling Pathway Regulation Of Signaling Regulation Of Signal Transduction Anatomical Structure Morphogenesis Regulation Of Cellular Component Organization Cellular Response To Growth Factor Stimulus Response To Growth Factor Regulation Of Phosphorylation Epidermal Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Cell Differentiation Cell Development Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Fc Receptor Signaling Pathway Cell Morphogenesis Involved In Differentiation Regulation Of Phosphorus Metabolic Process Positive Regulation Of Signal Transduction Anatomical Structure Development System Development Regulation Of Kinase Activity Intracellular Signal Transduction Developmental Process Regulation Of Protein Phosphorylation Neurotrophin TRK Receptor Signaling Pathway Immune Response-regulating Cell Surface Receptor Signaling Pathway Regulation Of Cellular Process Regulation Of Organelle Organization Neurotrophin Signaling Pathway Regulation Of Protein Kinase Activity Multicellular Organismal Development Neurogenesis Axon Guidance Regulation Of Protein Metabolic Process Cell Morphogenesis Involved In Neuron Differentiation Generation Of Neurons Axonogenesis Cell Communication Cell Projection Organization Tissue Development Cell Morphogenesis Positive Regulation Of Cellular Metabolic Process Regulation Of Intracellular Signal Transduction Vascular Endothelial Growth Factor Receptor Signaling Pathway Positive Regulation Of Metabolic Process Signaling Neuron Projection Morphogenesis Axon Development Regulation Of Metabolic Process Positive Regulation Of Protein Metabolic Process Defense Response
Tagcloud ?		agenesis axon axons bulb callosum collapse commissural commissures cone convergent corpus dcc deleted draxin explants forebrain guidance hetero heteros knockouts neogenin netrin neurite neurites olfactory outgrowth repulsion subnanomolar unc5s	advance belonging cdc2 cdc42 coordinate coordinates coordinating cot1 delays dystrophy encodes fission genetically interphase maintain maintains mitosis mitotic morphogenesis myotonic orb2 orb6 p34 polarity polarized ras1 shape shk1 threonine
Tagcloud (Difference) ?		agenesis axon axons bulb callosum collapse commissural commissures cone convergent corpus dcc deleted draxin explants forebrain guidance hetero heteros knockouts neogenin netrin neurite neurites olfactory outgrowth repulsion subnanomolar unc5s	advance belonging cdc2 cdc42 coordinate coordinates coordinating cot1 delays dystrophy encodes fission genetically interphase maintain maintains mitosis mitotic morphogenesis myotonic orb2 orb6 p34 polarity polarized ras1 shape shk1 threonine
Tagcloud (Intersection) ?