SETD2 and NDUFAF3

Data Source:
BioGRID (proximity labelling technology)

		SETD2	NDUFAF3
Description		SET domain containing 2, histone lysine methyltransferase	NADH:ubiquinone oxidoreductase complex assembly factor 3
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Chromosome	Nucleus Mitochondrial Inner Membrane
	Molecular Function	Protein Binding Protein-lysine N-methyltransferase Activity Histone-lysine N-methyltransferase Activity Alpha-tubulin Binding Metal Ion Binding Histone Methyltransferase Activity (H3-K36 Specific)	Protein Binding
	Biological Process	Angiogenesis Morphogenesis Of A Branching Structure Neural Tube Closure Mismatch Repair Regulation Of Transcription, DNA-templated Transcription Elongation From RNA Polymerase II Promoter Regulation Of Double-strand Break Repair Via Homologous Recombination Regulation Of MRNA Export From Nucleus Viral Process Peptidyl-lysine Trimethylation Peptidyl-lysine Monomethylation Forebrain Development Regulation Of Cytokinesis Positive Regulation Of Interferon-alpha Production Response To Type I Interferon Nucleosome Organization Cell Migration Involved In Vasculogenesis Endodermal Cell Differentiation Mesoderm Morphogenesis Embryonic Cranial Skeleton Morphogenesis Stem Cell Differentiation Stem Cell Development Defense Response To Virus Pericardium Development Embryonic Placenta Morphogenesis Coronary Vasculature Morphogenesis Histone H3-K36 Trimethylation Histone H3-K36 Dimethylation Microtubule Cytoskeleton Organization Involved In Mitosis Regulation Of Protein Localization To Chromatin	Mitochondrial Respiratory Chain Complex I Assembly
Pathways		PKMTs methylate histone lysines	Complex I biogenesis
Drugs
Diseases			Mitochondrial respiratory chain deficiencies (MRCD), including: Mitochondrial complex I deficiency (MT-C1D); Complex II deficiency (MT-C2D); Complex III deficiency (MT-C3D); Complex IV deficiency (MT-C4D); Complex V deficiency (MT-ATPSD); Leigh syndrome (LS); Kearns-Sayre Syndrome (KSS); LCHD deficiency (LCHD); Leber Hereditary Optic Neuropathy (LHON); Myoclonic Epilepsy and Ragged-Red Fiber Disease (MERRF); NARP; MELAS; ACAD9 deficiency; HADH deficiency; HIBCH deficiency; GRACILE syndrome
GWAS		Adult body size ( 32376654) Basophil count ( 32888494) Eosinophil counts ( 32888494) Eosinophil percentage of white cells ( 32888494) Granulocyte percentage of myeloid white cells ( 27863252) HDL cholesterol ( 24097068 30275531) HDL cholesterol levels ( 28334899) Huntington's disease progression ( 28642124) Lymphocyte counts ( 32888494 27863252) Lymphocyte percentage of white cells ( 32888494 27863252) Mean platelet volume ( 32888494) Medication use (HMG CoA reductase inhibitors) ( 31015401) Monocyte count ( 32888494 27863252) Monocyte percentage of white cells ( 32888494 27863252) Neutrophil count ( 32888494) Neutrophil percentage of white cells ( 32888494) Platelet distribution width ( 32888494 27863252) Post bronchodilator FEV1/FVC ratio ( 26634245) Refractive error ( 32231278) Waist-to-hip ratio adjusted for BMI (additive genetic model) ( 30778226) White blood cell count ( 32888494 27863252) White blood cell count (basophil) ( 27863252)	Blood protein levels ( 28240269) Brain morphology (min-P) ( 32665545) Brain morphology (MOSTest) ( 32665545) Cortical surface area (MOSTest) ( 32665545) Crohn's disease ( 28067908) Inflammatory bowel disease ( 28067908) Mood instability ( 31168069) Subcortical volume (min-P) ( 32665545) Subcortical volume (MOSTest) ( 32665545) Ulcerative colitis ( 28067908)
Interacting Genes		8 interacting genes: ATXN1 CIC H3-4 H3C1 HTT SIAH2 SMAD3 SPOP	17 interacting genes: AGTRAP CABP2 CYSRT1 GEM GOLGA6L9 INCA1 KRT27 KRTAP10-3 LSM1 MBD3L1 NDUFAF4 POU2AF1 RBCK1 REL RNF146 SNRPA UHMK1
Entrez ID		29072	25915
HPRD ID		11043	16809
Ensembl ID		ENSG00000181555	ENSG00000178057
Uniprot IDs		Q9BYW2	A4FU71 Q9BU61 Q9Y3Z0
PDB IDs		2A7O 2MDC 2MDI 2MDJ 4FMU 4H12 5JJY 5JLB 5JLE 5LSS 5LSX 5LSY 5LSZ 5LT6 5LT7 5LT8 5V21 5V22 6J9J 6VDB
Enriched GO Terms of Interacting Partners?
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