KAZN and NPPA

Data Source:
HPRD (in vivo, in vitro)

		KAZN	NPPA
Description		kazrin, periplakin interacting protein	natriuretic peptide A
Image		No pdb structure
GO Annotations	Cellular Component	Cornified Envelope Nucleoplasm Cytosol Cytoskeleton Nuclear Speck Desmosome	Extracellular Region Extracellular Space Nucleus Cytoplasm Protein-containing Complex Cell Projection Perikaryon Collagen-containing Extracellular Matrix
	Molecular Function	Protein Binding	Signaling Receptor Binding Hormone Activity Neuropeptide Hormone Activity Protein Binding Hormone Receptor Binding Neuropeptide Receptor Binding
	Biological Process	Cornification	Negative Regulation Of Systemic Arterial Blood Pressure Aortic Valve Morphogenesis CGMP Biosynthetic Process Transcription Initiation From RNA Polymerase II Promoter Protein Folding Receptor Guanylyl Cyclase Signaling Pathway Neuropeptide Signaling Pathway Female Pregnancy Regulation Of Blood Pressure Positive Regulation Of Heart Rate CGMP-mediated Signaling Response To Muscle Stretch Vasodilation Negative Regulation Of JUN Kinase Activity Cellular Protein Metabolic Process Regulation Of Atrial Cardiac Muscle Cell Membrane Repolarization Positive Regulation Of Cardiac Muscle Contraction Regulation Of High Voltage-gated Calcium Channel Activity Positive Regulation Of Delayed Rectifier Potassium Channel Activity Regulation Of Calcium Ion Transmembrane Transport Via High Voltage-gated Calcium Channel Positive Regulation Of Potassium Ion Export Across Plasma Membrane Regulation Of Cardiac Conduction
Pathways		Formation of the cornified envelope	YAP1- and WWTR1 (TAZ)-stimulated gene expression Physiological factors Amyloid fiber formation
Drugs
Diseases			Atrial fibrillation
GWAS		Body mass index ( 28552196) Cerebral amyloid deposition in APOEe4 non-carriers (PET imaging) ( 26252872) Chronotype ( 30696823) Conotruncal heart defects (inherited effects) ( 28468790) Copper levels ( 26025379) Lean body mass ( 28552196) Logical memory (delayed recall) in Alzheimer's disease dementia ( 29274321) Mercury levels ( 26025379) Moderate-to-late spontaneous preterm birth ( 31194736) Non-response to antidepressants and depression ( 27622933) Polycystic ovary syndrome (reproductive subtype) ( 32574161) Triacylglyceride levels ( 31551469) Urinary albumin-to-creatinine ratio in diabetes ( 31511532) Weight ( 28552196)	Atrial fibrillation ( 19597492) Diastolic blood pressure x smoking status (current vs non-current) interaction (2df test) ( 29455858) Diastolic blood pressure x smoking status (ever vs never) interaction (2df test) ( 29455858) Midregional pro atrial natriuretic peptide levels ( 29237677) Psoriasis ( 25854761) Pulse pressure ( 30578418) Systolic blood pressure ( 19430483 30578418) Systolic blood pressure x smoking status (current vs non-current) interaction (2df test) ( 29455858) Systolic blood pressure x smoking status (ever vs never) interaction (2df test) ( 29455858) Tuberculosis ( 29036319)
Interacting Genes		12 interacting genes: ARID5A CLVS2 COIL DVL3 LMO2 LZTS1 LZTS2 PPL PSMA1 TNS4 TXN2 USP2	14 interacting genes: EPB41 ESR1 HNF4A HSF2BP MAGEA12 MME NPR1 NPR2 NPR3 NR5A2 RORB UBQLN1 UBQLN2 UBQLN4
Entrez ID		23254	4878
HPRD ID		11122	00164
Ensembl ID		ENSG00000189337	ENSG00000175206
Uniprot IDs		Q674X7	P01160
PDB IDs			1ANP 1YK0 3N57
Enriched GO Terms of Interacting Partners?
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