THOC1 and DHX8

Data Source:
BioGRID (two hybrid)

		THOC1	DHX8
Description		THO complex 1	DEAH-box helicase 8
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GO Annotations	Cellular Component	Transcription Export Complex THO Complex THO Complex Part Of Transcription Export Complex Chromosome, Telomeric Region Nucleus Nucleoplasm Cytoplasm Nuclear Matrix Nuclear Speck	Intracellular Anatomical Structure Nucleus Nucleoplasm Spliceosomal Complex Cytosol Nuclear Body U2-type Catalytic Step 2 Spliceosome Catalytic Step 2 Spliceosome
	Molecular Function	DNA Binding RNA Binding Protein Binding	RNA Binding RNA Helicase Activity Protein Binding ATP Binding Identical Protein Binding
	Biological Process	Regulation Of DNA Recombination RNA Processing RNA Export From Nucleus MRNA Export From Nucleus Apoptotic Process Signal Transduction RNA Splicing MRNA 3'-end Processing Replication Fork Processing Regulation Of DNA-templated Transcription, Elongation Positive Regulation Of DNA-templated Transcription, Elongation Viral MRNA Export From Host Cell Nucleus Negative Regulation Of Isotype Switching To IgA Isotypes Negative Regulation Of DNA Damage Checkpoint	Spliceosomal Complex Disassembly MRNA Splicing, Via Spliceosome RNA Processing RNA Splicing
Pathways		Transport of Mature mRNA derived from an Intron-Containing Transcript mRNA 3'-end processing RNA Polymerase II Transcription Termination
Drugs
Diseases
GWAS		Bipolar disorder ( 20351715) Bipolar disorder or major depressive disorder ( 20351715) Height ( 31562340) Menarche (age at onset) ( 29773799) Triglyceride levels ( 32203549)	HDL cholesterol levels x long total sleep time interaction (2df test) ( 31719535)
Interacting Genes		26 interacting genes: AGR2 AKAP9 BHLHB9 CTAG1A CTAG1B DHX8 EXOC5 FRA10AC1 IK MAGEB4 MOAP1 MTNR1B NEDD4 PAX6 PPP1R12C RABGEF1 RB1 REL SAP30BP SF3B2 TADA2A TRIM27 TRIM54 USHBP1 WDR77 ZMYND12	11 interacting genes: MFAP1 NKAP PRPF38A PRPF40A RBM7 RBMX2 SAP30BP SRPK1 SRPK2 THOC1 ZCCHC10
Entrez ID		9984	1659
HPRD ID		09498	02672
Ensembl ID		ENSG00000079134	ENSG00000067596
Uniprot IDs		Q96FV9	B7Z8F4 F5H658 Q05CV4 Q14562 Q86YB2
PDB IDs		1WXP	2EQS 3I4U 5MQF 5XJC 6HYS 6HYT 6HYU 6ICZ 6QDV
Enriched GO Terms of Interacting Partners?
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