TNFSF15 and FKBP15

Data Source:
HPRD (in vitro)

		TNFSF15	FKBP15
Description		TNF superfamily member 15	FKBP prolyl isomerase family member 15
Image			No pdb structure
GO Annotations	Cellular Component	Extracellular Space Plasma Membrane Integral Component Of Plasma Membrane Integral Component Of Membrane	Early Endosome Membrane Growth Cone
	Molecular Function	Signaling Receptor Binding Cytokine Activity Tumor Necrosis Factor Receptor Binding Protein Binding	Peptidyl-prolyl Cis-trans Isomerase Activity Actin Binding Protein Binding
	Biological Process	Apoptotic Process Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Immune Response Signal Transduction Activation Of NF-kappaB-inducing Kinase Activity Tumor Necrosis Factor-mediated Signaling Pathway	Protein Peptidyl-prolyl Isomerization Endocytosis Negative Regulation Of Phosphatase Activity
Pathways		TNFs bind their physiological receptors
Drugs
Diseases		Crohn's disease
GWAS		Asthma ( 32296059) Chronic inflammatory diseases (ankylosing spondylitis, Crohn's disease, psoriasis, primary sclerosing cholangitis, ulcerative colitis) (pleiotropy) ( 26974007) Crohn's disease ( 18587394 30500874 21102463 32581322 26891255 23266558) Inflammatory bowel disease ( 27569725 18758464 23128233) Leprosy ( 20018961 25642632) Metabolite levels ( 23823483) Pediatric autoimmune diseases ( 26301688) Primary biliary cholangitis ( 28425483 23000144 28062665 30643196) Ulcerative colitis ( 20848476 21297633) Ulcerative colitis or Crohn's disease ( 21699788)
Interacting Genes		2 interacting genes: TNFRSF25 TNFRSF6B	1 interacting genes: RHOU
Entrez ID		9966	23307
HPRD ID		04956	19414
Ensembl ID		ENSG00000181634	ENSG00000119321
Uniprot IDs		A0A0U5JA19 O95150	Q5T1M5
PDB IDs		2O0O 2QE3 2RE9 2RJK 2RJL 3K51 3MI8
Enriched GO Terms of Interacting Partners?
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