Wiki-MPM
About
Search
Browse
People
Funding
Updates
Search
CDC6 and CDC14A
Data Source:
BioGRID
(enzymatic study)
CDC6
CDC14A
Description
cell division cycle 6
cell division cycle 14A
Image
No pdb structure
GO Annotations
Cellular Component
Spindle Pole
Nucleus
Nucleoplasm
Nucleolus
Cytoplasm
Cytosol
Intercellular Bridge
Spindle Midzone
Mitotic Spindle
Spindle Pole
Nucleoplasm
Nucleolus
Cytoplasm
Centrosome
Cytosol
Nuclear Body
Stereocilium Tip
Kinocilium
Mitotic Spindle
Kinociliary Basal Body
Molecular Function
Nucleotide Binding
DNA Replication Origin Binding
Protein Binding
ATP Binding
Kinase Binding
Protein Serine/threonine Phosphatase Activity
Protein Tyrosine Phosphatase Activity
Protein Binding
Protein Tyrosine/serine/threonine Phosphatase Activity
Protein Serine Phosphatase Activity
Protein Threonine Phosphatase Activity
Biological Process
DNA Replication Checkpoint
Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity
G1/S Transition Of Mitotic Cell Cycle
Regulation Of Transcription Involved In G1/S Transition Of Mitotic Cell Cycle
Mitotic Cell Cycle
DNA Replication
DNA Replication Initiation
Traversing Start Control Point Of Mitotic Cell Cycle
Negative Regulation Of DNA Replication
Negative Regulation Of Cell Population Proliferation
Regulation Of Mitotic Metaphase/anaphase Transition
Positive Regulation Of Cytokinesis
Mitotic DNA Replication Checkpoint
Positive Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity
Positive Regulation Of Fibroblast Proliferation
Cell Division
Positive Regulation Of Chromosome Segregation
Cellular Response To Vasopressin
Cellular Response To Angiotensin
Microtubule Cytoskeleton Organization
Mitotic Cell Cycle
Regulation Of Exit From Mitosis
Sensory Perception Of Sound
Positive Regulation Of Cytokinesis
Peptidyl-tyrosine Dephosphorylation
Cell Division
Cilium Assembly
Mitotic Cell Cycle Arrest
Pathways
Transcription of E2F targets under negative control by DREAM complex
Activation of ATR in response to replication stress
CDC6 association with the ORC:origin complex
CDT1 association with the CDC6:ORC:origin complex
Assembly of the pre-replicative complex
Orc1 removal from chromatin
Activation of the pre-replicative complex
CDK-mediated phosphorylation and removal of Cdc6
G1/S-Specific Transcription
Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase
MAPK6/MAPK4 signaling
Drugs
Diseases
GWAS
Asthma (
31619474
)
Estimated glomerular filtration rate (
31152163
31015462
)
Systolic blood pressure x educational attainment (some college) interaction (2df) (
32372009
)
Interacting Genes
38 interacting genes:
AKAP8L
ATM
ATRIP
B3GALNT1
CCNA2
CCNB1
CCNE1
CCNF
CDC14A
CDC20
CDK1
CDK2
CDK4
CDK6
CDKN1A
CDKN2A
CDT1
FZR1
KAT7
MCM10
MCM2
MCM3
MCM7
MYC
ORC1
ORC2
ORC3
ORC5
ORC6
PCNA
PPP2R3A
PPP2R3B
PSKH1
RPS27A
SQSTM1
TERF1
UBE2K
UBR1
15 interacting genes:
AATK
ATPAF2
BRAP
C14orf119
CDC25B
CDC6
CHRM1
FZR1
KIF20A
LMTK2
PLK1
POLR2A
PTK7
ROR2
TP53
Entrez ID
990
8556
HPRD ID
04022
04614
Ensembl ID
ENSG00000094804
ENSG00000079335
Uniprot IDs
A0A024R1S2
Q99741
A0A0U1RQX7
A0A2R8YDJ8
B4DY86
Q59EF4
Q9UNH5
PDB IDs
2CCH
2CCI
4I5L
4I5N
Enriched GO Terms of Interacting Partners
?
Tagcloud
?
Tagcloud (Difference)
?
Tagcloud (Intersection)
?