AREL1 and NPC2

Data Source:
BioGRID (biochemical)

		AREL1	NPC2
Description		apoptosis resistant E3 ubiquitin protein ligase 1	NPC intracellular cholesterol transporter 2
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GO Annotations	Cellular Component	Cytoplasm Cytosol	Extracellular Region Extracellular Space Lysosome Endoplasmic Reticulum Azurophil Granule Lumen Lysosomal Lumen Extracellular Exosome
	Molecular Function	Ubiquitin-protein Transferase Activity Protein Binding Ubiquitin Protein Ligase Activity	Protein Binding Cholesterol Binding Enzyme Binding Sterol Binding Cholesterol Transfer Activity
	Biological Process	Protein Polyubiquitination Ubiquitin-dependent Protein Catabolic Process Apoptotic Process Protein Ubiquitination Negative Regulation Of Apoptotic Process Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Protein Catabolic Process Regulation Of Inflammatory Response	Cholesterol Metabolic Process Response To Virus Phospholipid Transport Sterol Transport Regulation Of Isoprenoid Metabolic Process Cholesterol Transport Intracellular Sterol Transport Intracellular Cholesterol Transport Cholesterol Efflux Low-density Lipoprotein Particle Clearance Cholesterol Homeostasis Neutrophil Degranulation Glycolipid Transport Intermembrane Lipid Transfer
Pathways		Antigen processing: Ubiquitination & Proteasome degradation	Neutrophil degranulation LDL clearance
Drugs
Diseases			Niemann-Pick type C disease (NPC), including: Niemann-Pick disease, type C1; Niemann-Pick disease, type C2
GWAS		General factor of neuroticism ( 30867560) Mood instability ( 29187730)	Advanced glycation end-product levels ( 26915486) Blood protein levels ( 29875488) Intraocular pressure ( 31959993) Refractive error ( 32231278)
Interacting Genes		10 interacting genes: CRKL DIABLO HTRA2 PIAS4 SEPTIN4 UBC UBE2D1 UBE2D2 UBE2D3 UBE2L3	9 interacting genes: BARD1 BRCA1 DHDDS ECT2 ERRFI1 LIG4 PAXIP1 TRIM14 USP4
Entrez ID		9870	10577
HPRD ID		13794	03008
Ensembl ID		ENSG00000119682	ENSG00000119655
Uniprot IDs		O15033	A0A024R6C0 P61916
PDB IDs		6JX5	5KWY 6W5V
Enriched GO Terms of Interacting Partners?
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