CEP350 and APTX

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid)

		CEP350	APTX
Description		centrosomal protein 350	aprataxin
Image
GO Annotations	Cellular Component	Nucleus Cytoplasm Centrosome Centriole Spindle Membrane Cell Projection	Chromatin Nucleus Nucleoplasm Nucleolus Cytoplasm
	Molecular Function	Protein Binding Microtubule Binding	Chromatin Binding Damaged DNA Binding Double-stranded DNA Binding Single-stranded DNA Binding Double-stranded RNA Binding Protein Binding Phosphoglycolate Phosphatase Activity Mismatched DNA Binding DNA 5'-adenosine Monophosphate Hydrolase Activity Metal Ion Binding Protein N-terminus Binding Phosphoprotein Binding Single-strand Break-containing DNA Binding
	Biological Process	Microtubule Anchoring Protein Localization To Centrosome Non-motile Cilium Assembly	Single Strand Break Repair DNA Ligation Double-strand Break Repair Cellular Response To DNA Damage Stimulus Dephosphorylation Regulation Of Protein Stability Response To Hydrogen Peroxide Nucleic Acid Phosphodiester Bond Hydrolysis
Pathways
Drugs
Diseases			Coenzyme Q10 deficiency Ataxia with ocular apraxia (AOA), including: Ataxia telangiectasia (AT); Ataxia telangiectasia like disorder (ATLD); Ataxia oculomotor apraxia type 1 (AOA1); Ataxia oculomotor apraxia type 2 (AOA2)
GWAS		Anorexia nervosa ( 23568457) Mean corpuscular volume ( 32888494) Mean reticulocyte volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Smoking initiation ( 30617275)	Height ( 28552196) Menopause (age at onset) ( 26414677)
Interacting Genes		7 interacting genes: APTX CEP19 NR1H3 PLEKHA5 PPARA PPARD PPARG	18 interacting genes: CALCOCO1 CEP350 CNTROB FLAD1 HIVEP1 MAPKBP1 MBP PARP1 PICK1 PNMA1 PNMA3 SYT17 TP53 TRIM37 TSPYL2 XRCC1 XRCC4 ZNF639
Entrez ID		9857	54840
HPRD ID		09870	05892
Ensembl ID		ENSG00000135837	ENSG00000137074
Uniprot IDs		Q5VT06	Q7Z2E3
PDB IDs		2COZ	3KT9 4NDF 4NDG 4NDH 4NDI 6CVO 6CVP 6CVQ 6CVR 6CVS 6CVT
Enriched GO Terms of Interacting Partners?
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