HERPUD1 and CD58

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid)

		HERPUD1	CD58
Description		homocysteine inducible ER protein with ubiquitin like domain 1	CD58 molecule
Image
GO Annotations	Cellular Component	Endoplasmic Reticulum Endoplasmic Reticulum Membrane Membrane Integral Component Of Membrane Endoplasmic Reticulum Quality Control Compartment Lewy Body Core	Plasma Membrane Integral Component Of Plasma Membrane Cell Surface Membrane Secretory Granule Membrane Extracellular Exosome Ficolin-1-rich Granule Membrane
	Molecular Function	Molecular_function Protein Binding Ion Channel Binding Ubiquitin Ligase-substrate Adaptor Activity	Signaling Receptor Binding Protein Binding
	Biological Process	Ubiquitin-dependent Protein Catabolic Process Response To Unfolded Protein Protein Ubiquitination Ubiquitin-dependent ERAD Pathway Endoplasmic Reticulum Unfolded Protein Response Retrograde Protein Transport, ER To Cytosol Regulation Of Protein Ubiquitination Endoplasmic Reticulum Calcium Ion Homeostasis Response To Endoplasmic Reticulum Stress PERK-mediated Unfolded Protein Response Negative Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Protein Targeting To ER Negative Regulation Of Endoplasmic Reticulum Stress-induced Intrinsic Apoptotic Signaling Pathway Regulation Of ER-associated Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of ER-associated Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Intrinsic Apoptotic Signaling Pathway	Positive Regulation Of Interleukin-8 Production Heterotypic Cell-cell Adhesion Neutrophil Degranulation Leukocyte Migration Cellular Response To Interferon-gamma Cellular Response To Tumor Necrosis Factor Cell-cell Adhesion
Pathways		ATF4 activates genes in response to endoplasmic reticulum stress	Cell surface interactions at the vascular wall Neutrophil degranulation
Drugs
Diseases
GWAS		Cardiovascular risk factors ( 20838585) Coronary artery disease ( 29212778) Diisocyanate-induced asthma ( 25918132) HDL cholesterol ( 20031564 23505323 24886709) HDL Cholesterol in HIV-infection ( 25884002) HDL cholesterol levels ( 26763881 30698716) HDL cholesterol levels in current drinkers ( 30698716) HDL cholesterol levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) ( 30698716) HDL cholesterol levels x alcohol consumption (regular vs non-regular drinkers) interaction (2df) ( 30698716) High density lipoprotein cholesterol levels ( 29403010) Hypo-HDL-cholesterolemia ( 31087446) LDL cholesterol levels ( 30698716) LDL cholesterol levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) ( 30698716) LDL cholesterol levels x alcohol consumption (regular vs non-regular drinkers) interaction (2df) ( 30698716) Low HDL-cholesterol levels ( 31910446) Metabolic syndrome ( 20694148) Metabolite levels ( 23823483) Total cholesterol levels ( 29403010) Triglyceride levels ( 29403010) Triglyceride levels in current drinkers ( 30698716) Triglyceride levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) ( 30698716) Triglyceride levels x alcohol consumption (regular vs non-regular drinkers) interaction (2df) ( 30698716)	Multiple sclerosis ( 31604244 22190364 21244703 24076602 19525953 19525955 21833088 27386562) Primary biliary cholangitis ( 28425483) Systemic lupus erythematosus ( 33536424)
Interacting Genes		20 interacting genes: AMFR APP ARHGDIA C5AR2 CCR2 CD3D CD58 CHRM2 EWSR1 F2RL1 IMPA2 PSEN1 RPA2 SH3RF1 STARD9 TOLLIP UBQLN2 USP7 VCP XRCC6	4 interacting genes: APP CD2 DNAJA1 HERPUD1
Entrez ID		9709	965
HPRD ID		07456	01081
Ensembl ID		ENSG00000051108	ENSG00000116815
Uniprot IDs		A4UAE9 Q15011 Q53FP9	P19256
PDB IDs		1WGD	1CCZ 1CI5 1QA9
Enriched GO Terms of Interacting Partners?
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