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NUP93 and PLA2G6
Data Source:
BioGRID
(two hybrid)
NUP93
PLA2G6
Description
nucleoporin 93
phospholipase A2 group VI
Image
No pdb structure
GO Annotations
Cellular Component
Nuclear Envelope
Nuclear Pore
Membrane
Nuclear Membrane
Nuclear Periphery
Host Cell
Extracellular Space
Mitochondrion
Cytosol
Plasma Membrane
Integral Component Of Membrane
Pseudopodium
Centriolar Satellite
Molecular Function
Protein Binding
Structural Constituent Of Nuclear Pore
1-alkyl-2-acetylglycerophosphocholine Esterase Activity
Lysophospholipase Activity
Phospholipase A2 Activity
Protein Binding
Calmodulin Binding
Palmitoyl-CoA Hydrolase Activity
Hydrolase Activity
Identical Protein Binding
Calcium-independent Phospholipase A2 Activity
Phosphatidyl Phospholipase B Activity
Phospholipase A2 Activity (consuming 1,2-dipalmitoylphosphatidylcholine)
Phospholipase A2 Activity Consuming 1,2-dioleoylphosphatidylethanolamine)
Myristoyl-CoA Hydrolase Activity
Biological Process
Regulation Of Glycolytic Process
MRNA Export From Nucleus
TRNA Export From Nucleus
Protein Import Into Nucleus
Nuclear Envelope Organization
Viral Process
Protein Sumoylation
Poly(A)+ MRNA Export From Nucleus
Viral Transcription
Nuclear Pore Complex Assembly
Positive Regulation Of SMAD Protein Signal Transduction
SMAD Protein Signal Transduction
Regulation Of Gene Silencing By MiRNA
Intracellular Transport Of Virus
Regulation Of Cellular Response To Heat
Chemotaxis
Antibacterial Humoral Response
Cardiolipin Biosynthetic Process
Phosphatidylcholine Catabolic Process
Positive Regulation Of Insulin Secretion Involved In Cellular Response To Glucose Stimulus
Cardiolipin Acyl-chain Remodeling
Phosphatidylcholine Acyl-chain Remodeling
Phosphatidylethanolamine Acyl-chain Remodeling
Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis
Phosphatidylethanolamine Catabolic Process
Platelet Activating Factor Metabolic Process
Phosphatidic Acid Metabolic Process
Pathways
ISG15 antiviral mechanism
Transport of the SLBP independent Mature mRNA
Transport of the SLBP Dependant Mature mRNA
Transport of Mature mRNA Derived from an Intronless Transcript
Transport of Mature mRNA derived from an Intron-Containing Transcript
Rev-mediated nuclear export of HIV RNA
Transport of Ribonucleoproteins into the Host Nucleus
NS1 Mediated Effects on Host Pathways
Viral Messenger RNA Synthesis
NEP/NS2 Interacts with the Cellular Export Machinery
Regulation of Glucokinase by Glucokinase Regulatory Protein
Nuclear import of Rev protein
Vpr-mediated nuclear import of PICs
snRNP Assembly
SUMOylation of DNA damage response and repair proteins
SUMOylation of ubiquitinylation proteins
Nuclear Pore Complex (NPC) Disassembly
Regulation of HSF1-mediated heat shock response
SUMOylation of SUMOylation proteins
SUMOylation of chromatin organization proteins
SUMOylation of RNA binding proteins
SUMOylation of DNA replication proteins
SUMOylation of DNA replication proteins
Transcriptional regulation by small RNAs
Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC)
tRNA processing in the nucleus
HCMV Early Events
HCMV Late Events
Postmitotic nuclear pore complex (NPC) reformation
Postmitotic nuclear pore complex (NPC) reformation
Acyl chain remodelling of PC
Acyl chain remodeling of CL
Acyl chain remodelling of PE
Role of phospholipids in phagocytosis
COPI-independent Golgi-to-ER retrograde traffic
Drugs
Quinacrine
Diseases
Neurodegeneration with brain iron accumulation (NBIA); Hallervorden-Spatz syndrome; Neuroferritinopathy; Aceruloplasminemia
Parkinson's disease (PD)
GWAS
Apolipoprotein A1 levels (
32203549
)
Apolipoprotein B levels (
32203549
)
Gambling (
22780124
)
HDL cholesterol (
20031564
)
HDL cholesterol levels (
32203549
26763881
)
Potassium levels (
29403010
)
Apolipoprotein A1 levels (
32203549
)
Body fat percentage (
26833246
)
Brain morphology (MOSTest) (
32665545
)
Breast cancer (
29059683
)
C-reactive protein levels or triglyceride levels (pleiotropy) (
27286809
)
Cutaneous nevi (
21478494
19578365
)
HDL cholesterol levels (
32203549
)
High light scatter reticulocyte count (
32888494
)
Mammographic density (dense area) (
25342443
)
Melanoma (
21983787
28212542
)
Nevus count (
30429480
)
Nevus count or cutaneous melanoma (
32341527
30429480
)
Percent mammographic density (
25342443
)
Platelet distribution width (
32888494
)
Refractive error (
32231278
)
Reticulocyte count (
32888494
)
Triglyceride levels (
32203549
28334899
32154731
)
Triglycerides (
24097068
20686565
)
Interacting Genes
7 interacting genes:
AP5Z1
MPPED2
NDC1
NUP205
OPCML
PLA2G6
TMEM100
11 interacting genes:
CALM1
CCDC33
CEP76
MAT2B
NUP93
RCBTB2
RUSC1
SERTAD2
TRIM50
USP54
ZBTB42
Entrez ID
9688
8398
HPRD ID
14854
04675
Ensembl ID
ENSG00000102900
ENSG00000184381
Uniprot IDs
Q8N1F7
O60733
PDB IDs
5IJN
5IJO
Enriched GO Terms of Interacting Partners
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Tagcloud
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Tagcloud (Difference)
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Tagcloud (Intersection)
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