CEP135 and DCUN1D4

Data Source:
BioGRID (affinity chromatography technology)

		CEP135	DCUN1D4
Description		centrosomal protein 135	defective in cullin neddylation 1 domain containing 4
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GO Annotations	Cellular Component	Centrosome Centriole Cytosol	Ubiquitin Ligase Complex Nucleus
	Molecular Function	Protein Binding Protein C-terminus Binding	Protein Binding Ubiquitin Conjugating Enzyme Binding Ubiquitin-like Protein Binding Cullin Family Protein Binding
	Biological Process	G2/M Transition Of Mitotic Cell Cycle Centriole Replication Regulation Of G2/M Transition Of Mitotic Cell Cycle Centriole-centriole Cohesion Ciliary Basal Body-plasma Membrane Docking Positive Regulation Of Non-motile Cilium Assembly Positive Regulation Of Establishment Of Protein Localization	Protein Neddylation Positive Regulation Of Ubiquitin-protein Transferase Activity Positive Regulation Of Protein Neddylation
Pathways		Regulation of PLK1 Activity at G2/M Transition Loss of Nlp from mitotic centrosomes Recruitment of mitotic centrosome proteins and complexes Loss of proteins required for interphase microtubule organization from the centrosome Recruitment of NuMA to mitotic centrosomes Anchoring of the basal body to the plasma membrane AURKA Activation by TPX2	Neddylation
Drugs
Diseases
GWAS		Bone mineral density (hip) ( 30172743) Daytime sleep phenotypes ( 27126917) Femoral neck bone mineral density ( 30172743) Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) ( 26426971)	Estimated glomerular filtration rate ( 31152163) Familial squamous cell lung carcinoma ( 29924316) Height ( 28552196)
Interacting Genes		2 interacting genes: PIBF1 SMAD9	7 interacting genes: CAND1 CUL2 CUL3 CUL4A CUL4B UBE2M VAV2
Entrez ID		9662	23142
HPRD ID		11097	13791
Ensembl ID		ENSG00000174799	ENSG00000109184
Uniprot IDs		Q66GS9	B4DH26 Q92564
PDB IDs		5FCN 5NG4	5V89
Enriched GO Terms of Interacting Partners?
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