CEP135

Description		centrosomal protein 135
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GO Annotations	Cellular Component	Centrosome Centriole Cytosol
	Molecular Function	Protein Binding Protein C-terminus Binding
	Biological Process	G2/M Transition Of Mitotic Cell Cycle Centriole Replication Regulation Of G2/M Transition Of Mitotic Cell Cycle Centriole-centriole Cohesion Ciliary Basal Body-plasma Membrane Docking Positive Regulation Of Non-motile Cilium Assembly Positive Regulation Of Establishment Of Protein Localization
Pathways		Regulation of PLK1 Activity at G2/M Transition Loss of Nlp from mitotic centrosomes Recruitment of mitotic centrosome proteins and complexes Loss of proteins required for interphase microtubule organization from the centrosome Recruitment of NuMA to mitotic centrosomes Anchoring of the basal body to the plasma membrane AURKA Activation by TPX2
Drugs
Diseases
GWAS		Bone mineral density (hip) ( 30172743) Daytime sleep phenotypes ( 27126917) Femoral neck bone mineral density ( 30172743) Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) ( 26426971)
Novel Interacting Genes		5 novel interacting genes: CLOCK DCUN1D4 REST SPINK2 USP46
Interacting Genes		2 interacting genes: PIBF1 SMAD9
Entrez ID		9662
HPRD ID		11097
Ensembl ID		ENSG00000174799
Uniprot IDs		Q66GS9
PDB IDs		5FCN 5NG4
Enriched GO Terms of Interacting Partners?
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