SNCAIP and RNF19A

Data Source:
HPRD (in vitro)

		SNCAIP	RNF19A
Description		synuclein alpha interacting protein	ring finger protein 19A, RBR E3 ubiquitin protein ligase
Image			No pdb structure
GO Annotations	Cellular Component	Nucleoplasm Cytoplasm Cytosol Synaptic Vesicle Cytoplasmic Ribonucleoprotein Granule Presynaptic Membrane Neuronal Cell Body	Ubiquitin Ligase Complex Cytoplasm Centrosome Cytosol Integral Component Of Membrane Hippocampal Mossy Fiber To CA3 Synapse Postsynapse Glutamatergic Synapse
	Molecular Function	Protein Binding Ubiquitin Protein Ligase Binding Identical Protein Binding	Protein Binding Transcription Factor Binding Ubiquitin Conjugating Enzyme Binding Metal Ion Binding Ubiquitin Protein Ligase Activity
	Biological Process	Cell Death Dopamine Metabolic Process Cellular Protein Metabolic Process Regulation Of Neurotransmitter Secretion Regulation Of Inclusion Body Assembly	Protein Polyubiquitination Microtubule Cytoskeleton Organization Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Regulation Of Protein Catabolic Process At Postsynapse, Modulating Synaptic Transmission
Pathways		Amyloid fiber formation	Antigen processing: Ubiquitination & Proteasome degradation
Drugs
Diseases
GWAS		Chronic kidney disease (end stage renal disease vs. normal eGFR) in type 1 diabetes ( 31537649) Delirium ( 29631748) Depressive symptoms x independent stressful life events interaction (2df test) ( 30718454) Event free survival in diffuse large B-cell lymphoma treated with immunochemotherapy ( 26460308) Heart rate increase in response to exercise ( 29497042) Heart rate response to recovery post exercise (50 sec) ( 29497042) Mood disorder and prion disease ( 25897833) Response to paclitaxel in ovarian cancer (Caspase 3/7 EC50) ( 27047539)	Amyotrophic lateral sclerosis (sporadic) ( 24529757) Atrioventricular conduction ( 21041692) Recurrent major depressive disorder ( 29317602)
Interacting Genes		19 interacting genes: AGXT C11orf58 GET4 GSK3B NUB1 NUDT21 PIN1 PINK1 PPHLN1 PRKN PTN RNF19A SEPTIN4 SH2D3C SIAH1 SIAH2 SNCA TLE5 UBB	17 interacting genes: C11orf58 CASR ILK MAP3K20 MAP3K7 NUDT21 RPS6KA5 SNCAIP SOD1 SUFU TUBG1 TUBG2 UBE2D2 UBE2E2 UBE2L3 UBE2L6 VCP
Entrez ID		9627	25897
HPRD ID		04804	06176
Ensembl ID		ENSG00000064692	ENSG00000034677
Uniprot IDs		B7Z616 B7Z995 Q6L981 Q6L983 Q9Y6H5	Q9NV58
PDB IDs		2KES
Enriched GO Terms of Interacting Partners?
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