GMFG and PTGIS

Data Source:
BioGRID (biochemical)

		GMFG	PTGIS
Description		glia maturation factor gamma	prostaglandin I2 synthase
Image
GO Annotations	Cellular Component	Extracellular Region Secretory Granule Lumen Ficolin-1-rich Granule Lumen	Extracellular Space Nucleus Endoplasmic Reticulum Endoplasmic Reticulum Membrane Caveola Integral Component Of Membrane
	Molecular Function	Actin Binding Protein Kinase Inhibitor Activity Enzyme Activator Activity Growth Factor Activity Arp2/3 Complex Binding	Monooxygenase Activity Iron Ion Binding Protein Binding Prostaglandin-I Synthase Activity Oxidoreductase Activity, Acting On Paired Donors, With Incorporation Or Reduction Of Molecular Oxygen Heme Binding Hydroperoxy Icosatetraenoate Dehydratase Activity
	Biological Process	Protein Phosphorylation Negative Regulation Of Protein Kinase Activity Signal Transduction Negative Regulation Of Arp2/3 Complex-mediated Actin Nucleation Neutrophil Degranulation Actin Filament Debranching Regulation Of Actin Cytoskeleton Reorganization	Prostaglandin Biosynthetic Process Icosanoid Metabolic Process Cyclooxygenase Pathway Negative Regulation Of NF-kappaB Transcription Factor Activity NAD Biosynthesis Via Nicotinamide Riboside Salvage Pathway Positive Regulation Of Peroxisome Proliferator Activated Receptor Signaling Pathway Negative Regulation Of Nitric Oxide Biosynthetic Process Positive Regulation Of Angiogenesis Negative Regulation Of Inflammatory Response Cellular Response To Interleukin-1 Cellular Response To Interleukin-6 Cellular Response To Hypoxia Apoptotic Signaling Pathway Positive Regulation Of Execution Phase Of Apoptosis
Pathways		Neutrophil degranulation	Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol Synthesis of bile acids and bile salts via 24-hydroxycholesterol Synthesis of bile acids and bile salts via 27-hydroxycholesterol Nicotinamide salvaging Eicosanoids Sterols are 12-hydroxylated by CYP8B1 Synthesis of Prostaglandins (PG) and Thromboxanes (TX)
Drugs			Phenylbutazone Epoprostenol (5Z)-7-{(1R,4S,5R,6R)-6-[(1E)-1-Octen-1-yl]-2,3-diazabicyclo[2.2.1]hept-2-en-5-yl}-5-heptenoic acid
Diseases
GWAS		Lung adenocarcinoma ( 28604730)	anorexia nervosa, attention-deficit/hyperactivity disorder, autism spectrum disorder, bipolar disorder, major depression, obsessive-compulsive disorder, schizophrenia, or Tourette syndrome (pleiotropy) ( 31835028) Schizophrenia ( 25056061 29483656 30285260)
Interacting Genes		3 interacting genes: CAMK1D PSD VANGL1	3 interacting genes: APP PTGS1 PTGS2
Entrez ID		9535	5740
HPRD ID		06821	09046
Ensembl ID		ENSG00000130755	ENSG00000124212
Uniprot IDs		M0R1D2 O60234	Q16647
PDB IDs		3L50	2IAG 3B6H
Enriched GO Terms of Interacting Partners?
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