ADAMTS1 and TPSAB1

Data Source:
BioGRID (affinity chromatography technology)

		ADAMTS1	TPSAB1
Description		ADAM metallopeptidase with thrombospondin type 1 motif 1	tryptase alpha/beta 1
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GO Annotations	Cellular Component	Basement Membrane Extracellular Matrix Cytoplasmic Vesicle Collagen-containing Extracellular Matrix	Extracellular Region Extracellular Space Collagen-containing Extracellular Matrix
	Molecular Function	Metalloendopeptidase Activity Protein Binding Heparin Binding Metallopeptidase Activity Zinc Ion Binding	Serine-type Endopeptidase Activity Protein Binding Serine-type Peptidase Activity Identical Protein Binding
	Biological Process	Ovulation From Ovarian Follicle Kidney Development Proteolysis Integrin-mediated Signaling Pathway Negative Regulation Of Cell Population Proliferation Negative Regulation Of Angiogenesis Extracellular Matrix Organization Heart Trabecula Formation Positive Regulation Of G1/S Transition Of Mitotic Cell Cycle Positive Regulation Of Vascular Associated Smooth Muscle Cell Proliferation Positive Regulation Of Vascular Associated Smooth Muscle Cell Migration	Proteolysis Defense Response Extracellular Matrix Disassembly
Pathways		Degradation of the extracellular matrix Defective B3GALTL causes Peters-plus syndrome (PpS) O-glycosylation of TSR domain-containing proteins	Activation of Matrix Metalloproteinases
Drugs			Amido Phenyl Pyruvic Acid 4-PIPERIDIN-4-YLBUTANAL [4-(3-AMINOMETHYL-PHENYL)-PIPERIDIN-1-YL]-(5-PHENETHYL- PYRIDIN-3-YL)-METHANONE 1-(1'-{[3-(methylsulfanyl)-2-benzothiophen-1-yl]carbonyl}spiro[1-benzofuran-3,4'-piperidin]-5-yl)methanamine 1-[1'-(3-phenylacryloyl)spiro[1-benzofuran-3,4'-piperidin]-5-yl]methanamine JNJ-27390467
Diseases
GWAS		Alzheimer's disease (late onset) ( 30820047) Blood protein levels ( 28240269) Cerebrospinal fluid neurofilament light levels ( 31930058) Health literacy ( 31250787) Metabolite levels ( 23823483)	Blood protein levels ( 30072576 29875488 28240269)
Interacting Genes		7 interacting genes: A2M ACAN FURIN KRT40 KRTAP10-8 VCAN VEGFA
Entrez ID		9510	7177
HPRD ID		05530	01849
Ensembl ID		ENSG00000154734	ENSG00000172236
Uniprot IDs		B2RB33 Q9UHI8	P20231 Q15661
PDB IDs		2JIH 2V4B 3Q2G 3Q2H	1A0L 1AAO 1LTO 2BM2 2F9N 2F9O 2F9P 2FPZ 2FS8 2FS9 2FWW 2FXR 2GDD 2ZA5 2ZEB 2ZEC 3V7T 4A6L 4MPU 4MPV 4MPW 4MPX 4MQA 5F03 5WI6 6O1F 6P0P
Enriched GO Terms of Interacting Partners?
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