MAGED1 and GLRA1

Data Source:
BioGRID (two hybrid)

		MAGED1	GLRA1
Description		MAGE family member D1	glycine receptor alpha 1
Image		No pdb structure
GO Annotations	Cellular Component	Chromatin Nucleus Cytoplasm Plasma Membrane Protein-containing Complex	Endoplasmic Reticulum Plasma Membrane Integral Component Of Plasma Membrane External Side Of Plasma Membrane Integral Component Of Membrane Dendrite Chloride Channel Complex Neuron Projection Neuronal Cell Body Perikaryon Intracellular Membrane-bounded Organelle Calyx Of Held Synapse Postsynaptic Membrane Inhibitory Synapse Glycinergic Synapse Integral Component Of Presynaptic Membrane Integral Component Of Postsynaptic Specialization Membrane
	Molecular Function	Protein Binding Identical Protein Binding	Transmembrane Signaling Receptor Activity Chloride Channel Activity Protein Binding Zinc Ion Binding Glycine Binding Extracellularly Glycine-gated Chloride Channel Activity Neurotransmitter Receptor Activity Taurine Binding Identical Protein Binding Protein-containing Complex Binding Transmitter-gated Ion Channel Activity Involved In Regulation Of Postsynaptic Membrane Potential
	Biological Process	Regulation Of Transcription, DNA-templated Circadian Regulation Of Gene Expression Regulation Of Apoptotic Process Negative Regulation Of Epithelial Cell Proliferation	Action Potential Startle Response Regulation Of Respiratory Gaseous Exchange By Nervous System Process Ion Transport Chloride Transport Muscle Contraction Signal Transduction Neuropeptide Signaling Pathway Chemical Synaptic Transmission Acrosome Reaction Visual Perception Adult Walking Behavior Ion Transmembrane Transport Regulation Of Membrane Potential Response To Amino Acid Nervous System Process Neuromuscular Process Controlling Posture Negative Regulation Of Transmission Of Nerve Impulse Synaptic Transmission, Glycinergic Righting Reflex Excitatory Postsynaptic Potential Inhibitory Postsynaptic Potential Cellular Response To Amino Acid Stimulus Cellular Response To Zinc Ion Cellular Response To Ethanol Response To Alcohol Chloride Transmembrane Transport Positive Regulation Of Acrosome Reaction
Pathways		NRAGE signals death through JNK Caspase activation via Dependence Receptors in the absence of ligand	Neurotransmitter receptors and postsynaptic signal transmission Neurotransmitter receptors and postsynaptic signal transmission
Drugs			Glycine Enflurane Lindane Picrotoxin Atropine Isoflurane Ethanol Methoxyflurane Memantine Halothane Desflurane Sevoflurane Ginkgo biloba Zinc Taurine D-Serine GW 468816 Seletracetam Cannabidiol Cannabidiol Copper Thiocolchicoside Medical Cannabis Medical Cannabis Nabiximols Nabiximols Zinc acetate Zinc chloride Zinc sulfate, unspecified form
Diseases			Hyperekplexia
GWAS			Morning person ( 30696823)
Interacting Genes		125 interacting genes: AGRN AKAP9 ARHGEF16 ARID5A ARNT2 BAG3 BAG4 BARD1 BHLHE40 BIRC8 BRCA2 C1orf94 CA8 CAPN7 CCDC120 CCDC33 CDC23 CERCAM CFAP206 CHERP DAB1 DAZAP2 DDX6 DLX4 DLX5 DMRT2 EIF3J EIF4E2 EP300 ERCC3 FAM83A FOXD2 FOXH1 FOXI1 GATA5 GLRA1 GLYCTK GPANK1 GPR135 GRAP2 HEMK1 HGS HIVEP1 HNRNPH1 HNRNPLL HOXC9 HSF2BP KPNA2 KPNA6 KRTAP19-5 KRTAP6-1 KRTAP6-3 LARP4B LENG8 LONRF1 MAPK1IP1L MAPK3 MDFI MEOX2 MGAT5B MKRN3 MPC1 MSX2 NAF1 NGFR NOTCH1 NOTO NPAS4 NUMBL PHF1 PITX1 PJA1 PJA2 PLK1 PNMA5 POM121 PRKAB2 PROP1 PRR20A PRR20B PRR20C PRR20D PRR20E PRR35 PSMF1 RAMAC RBFOX1 RBFOX2 RBM23 RBPMS RBPMS2 RFX1 RHOXF2 RNF6 RNF8 ROR2 RUSC1 RXFP4 SIM2 SIRT7 SMAP2 SMN1 SMN2 SNRPC SOX10 SOX5 TBX6 TFG TIAL1 TLX3 TRAF4 TRIM28 TSGA10IP TTC23 TTC32 TUBA4A UBQLN2 UNC5A VENTX XIAP YTHDF1 ZFYVE26 ZIC1 ZNF488 ZNF688	2 interacting genes: MAGED1 SORBS3
Entrez ID		9500	2741
HPRD ID		02202	00719
Ensembl ID		ENSG00000179222	ENSG00000145888
Uniprot IDs		Q9Y5V3	P23415 Q14C71
PDB IDs			1MOT 1VRY 2M6B 2M6I 4X5T
Enriched GO Terms of Interacting Partners?
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