SLC4A7 and SLC4A4

Data Source:
HPRD (in vivo)

		SLC4A7	SLC4A4
Description		solute carrier family 4 member 7	solute carrier family 4 member 4
Image		No pdb structure
GO Annotations	Cellular Component	Plasma Membrane Membrane Integral Component Of Membrane Basolateral Plasma Membrane Apical Plasma Membrane Cytoplasmic Vesicle Stereocilium Synapse	Plasma Membrane Integral Component Of Plasma Membrane Cell Surface Membrane Basolateral Plasma Membrane Spanning Component Of Plasma Membrane Extracellular Exosome
	Molecular Function	Inorganic Anion Exchanger Activity Protein Binding Sodium:bicarbonate Symporter Activity Transmembrane Transporter Activity	Inorganic Anion Exchanger Activity Protein Binding Sodium:bicarbonate Symporter Activity Symporter Activity Transmembrane Transporter Activity Identical Protein Binding
	Biological Process	Inorganic Anion Transport Bicarbonate Transport Sodium Ion Transmembrane Transport Ion Homeostasis Regulation Of Intracellular PH Transmembrane Transport Auditory Receptor Cell Development Anion Transmembrane Transport	Sodium Ion Transport Inorganic Anion Transport Bicarbonate Transport Sodium Ion Transmembrane Transport Sodium Ion Export Across Plasma Membrane Regulation Of Membrane Potential Positive Regulation Of Glycolytic Process Ion Homeostasis Regulation Of Intracellular PH Transmembrane Transport Anion Transmembrane Transport Transport Across Blood-brain Barrier
Pathways		Bicarbonate transporters	Bicarbonate transporters Defective SLC4A4 causes renal tubular acidosis, proximal, with ocular abnormalities and mental retardation (pRTA-OA)
Drugs
Diseases			Proximal renal tubular acidosis (RTA type 2)
GWAS		Blood pressure ( 21909110) Breast cancer ( 21263130 29059683 23535729 20453838 19330027) Breast cancer (early onset) ( 24493630) Diastolic blood pressure ( 27841878 21909115 28739976 27618447 27618452 25249183) Diastolic blood pressure (cigarette smoking interaction) ( 29455858) Diastolic blood pressure x alcohol consumption interaction (2df test) ( 29912962) Diastolic blood pressure x smoking status (current vs non-current) interaction (2df test) ( 29455858) Diastolic blood pressure x smoking status (ever vs never) interaction (2df test) ( 29455858) Hypertension ( 25249183) Lymphocyte counts ( 32888494) Macular thickness ( 30535121) Mean arterial pressure ( 29403010 27618448) Mean arterial pressure x alcohol consumption (light vs heavy) interaction (2df test) ( 29912962) Mean arterial pressure x alcohol consumption interaction (2df test) ( 29912962) Medication use (beta blocking agents) ( 31015401) Medication use (diuretics) ( 31015401) Monocyte count ( 32888494) Platelet count ( 32888494) Platelet distribution width ( 32888494) Plateletcrit ( 32888494) Pulse pressure ( 29403010 30578418) Pulse pressure x alcohol consumption interaction (2df test) ( 29912962) Systolic blood pressure ( 28135244 21909115 29403010 28739976 27618452 25249183 30578418) Systolic blood pressure (cigarette smoking interaction) ( 29455858) Systolic blood pressure x alcohol consumption (light vs heavy) interaction (2df test) ( 29912962) Systolic blood pressure x alcohol consumption interaction (2df test) ( 29912962) Systolic blood pressure x smoking status (current vs non-current) interaction (2df test) ( 29455858) Systolic blood pressure x smoking status (ever vs never) interaction (2df test) ( 29455858) Urinary potassium excretion ( 31409800) Urinary potassium to creatinine ratio ( 30910378) Uterine fibroids ( 30194396)	Age-related nuclear cataracts ( 24951543) Diastolic blood pressure ( 30578418) Fractional exhaled nitric oxide (childhood) ( 24315451) Gut microbiota relative abundance (Faecalibacterium) ( 33208821) Heel bone mineral density ( 30598549 28869591) Mosquito bite size ( 28199695) QT interval ( 24952745 29874175) Refractive error ( 32231278)
Interacting Genes		7 interacting genes: CFTR CIAO1 KRTAP4-5 MTNR1B SLC4A4 SLC9A3R1 YWHAB	5 interacting genes: CA2 CA4 PRKACA SLC4A7 SREBF2
Entrez ID		9497	8671
HPRD ID		04521	04516
Ensembl ID		ENSG00000033867	ENSG00000080493
Uniprot IDs		B5M450 E9PFN4 Q9Y6M7	A5JJ20 Q9Y6R1
PDB IDs			6CAA
Enriched GO Terms of Interacting Partners?
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