PIGB and RHEB

Data Source:
BioGRID (affinity chromatography technology)

		PIGB	RHEB
Description		phosphatidylinositol glycan anchor biosynthesis class B	Ras homolog, mTORC1 binding
Image		No pdb structure
GO Annotations	Cellular Component	Endoplasmic Reticulum Membrane Integral Component Of Membrane	Golgi Membrane Spliceosomal Complex Lysosomal Membrane Endoplasmic Reticulum Membrane Cytosol Plasma Membrane Postsynaptic Density Membrane Extracellular Exosome
	Molecular Function	Alpha-1,2-mannosyltransferase Activity Mannosyltransferase Activity Glycolipid Mannosyltransferase Activity	Magnesium Ion Binding GTPase Activity Protein Binding GTP Binding GDP Binding Protein Kinase Binding
	Biological Process	GPI Anchor Biosynthetic Process Preassembly Of GPI Anchor In ER Membrane Mannosylation	Cell Cycle Arrest Signal Transduction Small GTPase Mediated Signal Transduction Regulation Of Macroautophagy Positive Regulation Of TOR Signaling Positive Regulation Of Oligodendrocyte Differentiation Negative Regulation Of Cold-induced Thermogenesis Regulation Of Type B Pancreatic Cell Development
Pathways		Synthesis of glycosylphosphatidylinositol (GPI)	Macroautophagy MTOR signalling mTORC1-mediated signalling Energy dependent regulation of mTOR by LKB1-AMPK TP53 Regulates Metabolic Genes Regulation of PTEN gene transcription Amino acids regulate mTORC1
Drugs			Guanosine-5'-Triphosphate Guanosine-5'-Diphosphate
Diseases
GWAS			Carboplatin disposition in epthelial ovarian cancer ( 29367611) Metabolite levels ( 23823483)
Interacting Genes			29 interacting genes: A2M APOE APPBP2 ARIH2 ATM ATR BNIP3 BNIP3L BRAF CREB3 ECSIT FKBP8 HTT MTOR NCAM1 PDE6D PLD1 PSEN1 PSEN2 RABAC1 RAF1 RNF152 RPS6KB1 RPTOR TRIM55 TRIM63 TSC1 TSC2 USP4
Entrez ID		9488	6009
HPRD ID		04988	03188
Ensembl ID		ENSG00000069943	ENSG00000106615
Uniprot IDs		Q92521	A0A090N900 Q15382
PDB IDs			1XTQ 1XTR 1XTS 3SEA 3T5G 5YXH 6BCU 6BSX 6BT0 7BTA 7BTC 7BTD
Enriched GO Terms of Interacting Partners?
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