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ITM2A and FCGR1A
Data Source:
BioGRID
(two hybrid)
ITM2A
FCGR1A
Description
integral membrane protein 2A
Fc fragment of IgG receptor Ia
Image
No pdb structure
GO Annotations
Cellular Component
Golgi Apparatus
Plasma Membrane
Integral Component Of Membrane
Plasma Membrane
Integral Component Of Plasma Membrane
Clathrin-coated Endocytic Vesicle Membrane
Early Endosome Membrane
Molecular Function
Amyloid-beta Binding
Protein Binding
Transmembrane Signaling Receptor Activity
Protein Binding
IgG Binding
Biological Process
Plasma Cell Differentiation
Negative Regulation Of Amyloid Precursor Protein Biosynthetic Process
Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class I, TAP-dependent
Receptor-mediated Endocytosis
Phagocytosis, Engulfment
Immune Response
Signal Transduction
Cell Surface Receptor Signaling Pathway
Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis
Regulation Of Immune Response
Interferon-gamma-mediated Signaling Pathway
Positive Regulation Of Protein Tyrosine Kinase Activity
Pathways
Cross-presentation of soluble exogenous antigens (endosomes)
Cross-presentation of soluble exogenous antigens (endosomes)
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
FCGR activation
FCGR activation
Regulation of actin dynamics for phagocytic cup formation
Role of phospholipids in phagocytosis
Interferon gamma signaling
FCGR3A-mediated IL10 synthesis
Drugs
Cetuximab
Etanercept
Human immunoglobulin G
Gemtuzumab ozogamicin
Alemtuzumab
Natalizumab
Palivizumab
Daclizumab
Bevacizumab
Porfimer sodium
Catumaxomab
Sarilumab
Trastuzumab deruxtecan
Diseases
GWAS
Birth weight (
31043758
)
Graves' disease (
23612905
)
Height (
18391951
)
Nose size (
27182965
)
Thyrotoxic hypokalemic periodic paralysis and Graves disease (
31050781
)
Interacting Genes
7 interacting genes:
CLDN7
FCGR1A
FNDC9
MEOX2
SIT1
TMED9
TRIM14
30 interacting genes:
ADIPOQ
APCS
ASGR1
BIK
BMP10
CD163
CLDN19
CLEC7A
CRKL
CRP
FAM3C
FCAR
FCGR3A
HCK
HRG
ITM2A
JAGN1
LAT
LHFPL5
LILRB2
MALL
NINJ1
NRSN1
RPRM
SYK
TNMD
TSPO2
UPK2
VSTM1
VTI1B
Entrez ID
9452
2209
HPRD ID
02200
00904
Ensembl ID
ENSG00000078596
ENSG00000150337
Uniprot IDs
O43736
P12314
PDB IDs
3RJD
4W4O
4X4M
4ZNE
Enriched GO Terms of Interacting Partners
?
Tagcloud
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Tagcloud (Difference)
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Tagcloud (Intersection)
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