NCR1 and CD59

Data Source:
HPRD (in vivo)

		NCR1	CD59
Description		natural cytotoxicity triggering receptor 1	CD59 molecule (CD59 blood group)
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GO Annotations	Cellular Component	Plasma Membrane Integral Component Of Plasma Membrane SWI/SNF Complex	Golgi Membrane Extracellular Space Endoplasmic Reticulum Membrane Plasma Membrane Focal Adhesion Cell Surface ER To Golgi Transport Vesicle Membrane Membrane Transport Vesicle Anchored Component Of External Side Of Plasma Membrane Vesicle Endoplasmic Reticulum-Golgi Intermediate Compartment Membrane Specific Granule Membrane Extracellular Exosome Tertiary Granule Membrane
	Molecular Function	Protein Binding	Complement Binding Protein Binding
	Biological Process	Cellular Defense Response Signal Transduction Natural Killer Cell Activation Regulation Of Natural Killer Cell Mediated Cytotoxicity Regulation Of Immune Response	Negative Regulation Of Activation Of Membrane Attack Complex Endoplasmic Reticulum To Golgi Vesicle-mediated Transport Cell Surface Receptor Signaling Pathway Blood Coagulation Regulation Of Complement Activation Neutrophil Degranulation COPII Vesicle Coating Regulation Of Complement-dependent Cytotoxicity
Pathways		Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell	COPII-mediated vesicle transport Cargo concentration in the ER Neutrophil degranulation COPI-mediated anterograde transport Regulation of Complement cascade
Drugs
Diseases			Complement regulatory protein defects, including the following six diseases: C1 inhibitor deficiency (hereditary angioedema); C4 binding protein alpha deficiency; C4 binding protein beta deficiency; Factor I deficiency; Decay-accelerating factor (CD55) deficiency; CD59 deficiency
GWAS		Blood protein levels ( 30072576 29875488) Metabolite levels ( 23823483) Monocyte percentage of white cells ( 32888494)	Blood protein levels ( 30072576 29875488) Body size at age 10 ( 32376654) Chronotype ( 30696823) Fruit consumption ( 32066663) Morning person ( 30696823)
Interacting Genes		8 interacting genes: ADAM33 APP CD247 CD59 FCER1G RHOU TMEM229B TMEM50B	16 interacting genes: C8A C9 CCR2 CD2 CD8A CD9 CHRM4 EGFR FAM209A GNAI3 NCR1 NCR3 SLC13A1 SLC6A8 SMAD4 SRC
Entrez ID		9437	966
HPRD ID		05167	00117
Ensembl ID		ENSG00000189430	ENSG00000085063
Uniprot IDs		A0A0A0MQZ0 A0A0A0MR94 A0A0A0MTU0 O76036	P13987 Q6FHM9
PDB IDs		1OLL 1P6F 6IAP	1CDQ 1CDR 1CDS 1ERG 1ERH 2J8B 2OFS 2UWR 2UX2 4BIK 5IMT 5IMY
Enriched GO Terms of Interacting Partners?
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