TRIP11 and EPS8

Data Source:
BioGRID (biochemical)

		TRIP11	EPS8
Description		thyroid hormone receptor interactor 11	epidermal growth factor receptor pathway substrate 8
Image		No pdb structure
GO Annotations	Cellular Component	Golgi Membrane Inner Acrosomal Membrane Outer Acrosomal Membrane Nucleoplasm Endoplasmic Reticulum-Golgi Intermediate Compartment Golgi Apparatus Cis-Golgi Network Cytoskeleton Cilium Nuclear Speck Transport Vesicle Endoplasmic Reticulum-Golgi Intermediate Compartment Membrane	Plasma Membrane Cell Cortex Growth Cone Vesicle Stereocilium Ruffle Membrane Synapse Extracellular Exosome
	Molecular Function	Transcription Coactivator Activity Protein Binding Small GTPase Binding	Actin Binding Protein Binding Small GTPase Binding Signaling Adaptor Activity
	Biological Process	Ventricular Septum Development Chondrocyte Differentiation Involved In Endochondral Bone Morphogenesis Transcription By RNA Polymerase II Protein Glycosylation Endoplasmic Reticulum To Golgi Vesicle-mediated Transport Golgi Organization Intraciliary Transport Involved In Cilium Assembly Positive Regulation Of Transcription, DNA-templated Cartilage Development Inner Ear Receptor Cell Stereocilium Organization Golgi Ribbon Formation Vesicle Tethering To Golgi	Rho Protein Signal Transduction Regulation Of Cell Shape Exit From Mitosis Rac Protein Signal Transduction Regulation Of Actin Filament Length Regulation Of Rho Protein Signal Transduction Dendritic Cell Migration Regulation Of Catalytic Activity Barbed-end Actin Filament Capping Actin Filament Bundle Assembly Actin Crosslink Formation Actin Polymerization-dependent Cell Motility Positive Regulation Of Ruffle Assembly
Pathways		Intraflagellar transport Intra-Golgi traffic Signaling by FLT3 fusion proteins Signaling by FLT3 fusion proteins
Drugs
Diseases		Achodrogenesis type IA
GWAS		Body size at age 10 ( 32376654) FEV1 ( 30804560) HDL cholesterol levels x thiazide or thiazide-like diuretics use interaction ( 31806883) Height ( 28552196 20881960 25282103 25429064 31562340 18391950 18391951) LDL cholesterol levels x loop diuretics use interaction ( 31806883) Lung function (FEV1) ( 26635082) Lung function (FVC) ( 26635082 30804560) Refractive error ( 32231278) Waist circumference adjusted for BMI (adjusted for smoking behaviour) ( 28443625) Waist circumference adjusted for BMI (joint analysis main effects and physical activity interaction) ( 28448500) Waist circumference adjusted for BMI (joint analysis main effects and smoking interaction) ( 28443625) Waist circumference adjusted for BMI in active individuals ( 28448500) Waist circumference adjusted for BMI in non-smokers ( 28443625) Waist circumference adjusted for body mass index ( 25673412 28448500)	Metabolite levels ( 23823483) Protein quantitative trait loci ( 18464913)
Interacting Genes		6 interacting genes: ARNT ATXN1L MYBPC2 PSMC5 RB1 THRA	61 interacting genes: ABI1 ACTA1 ADAM22 AIMP2 ALDH7A1 ARMC1 BAIAP2 BCKDK BLOC1S6 BORCS6 BYSL C19orf25 C6orf141 C8orf33 CASK CBL CCDC85B CSNK2B CTNNA3 CXCL2 DNALI1 DVL1 EGFR GOLGA8EP GRB2 GULP1 HNRNPC HOOK2 INPP5J ITGB1 ITGB3 ITGB5 ITSN2 MAP1LC3B MAP3K11 MRPL20 MYO15A NACC2 NFKB2 PCM1 PROSER2 RCAN3 RFXAP RSPH14 RUNX1T1 SCRN3 SERPINA5 SF3B3 SHB SHC1 SLC27A4 SMARCE1 SOS1 SRC TDP2 TEX28 TPRN USP6NL XAGE2 XRCC6 ZZZ3
Entrez ID		9321	2059
HPRD ID		05143	02563
Ensembl ID		ENSG00000100815	ENSG00000151491
Uniprot IDs		Q15643	B4E3T6 Q12929
PDB IDs			2E8M
Enriched GO Terms of Interacting Partners?
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