Wiki-MPM
About
Search
Browse
People
Funding
Updates
Search
HELB and POLA1
Data Source:
HPRD
(in vivo, in vitro)
HELB
POLA1
Description
DNA helicase B
DNA polymerase alpha 1, catalytic subunit
Image
No pdb structure
GO Annotations
Cellular Component
Intracellular Anatomical Structure
Nucleus
DNA Replication Factor A Complex
Nucleolus
Cytoplasm
Site Of Double-strand Break
Chromatin
Nucleus
Nuclear Envelope
Nucleoplasm
Alpha DNA Polymerase:primase Complex
Nucleolus
Cytosol
Nuclear Matrix
Molecular Function
RNA Binding
ATP Binding
Single-stranded DNA Helicase Activity
5'-3' DNA Helicase Activity
Protein-containing Complex Binding
Nucleotide Binding
DNA Binding
Chromatin Binding
DNA Replication Origin Binding
Single-stranded DNA Binding
DNA-directed DNA Polymerase Activity
Protein Binding
Purine Nucleotide Binding
Pyrimidine Nucleotide Binding
Protein Kinase Binding
Metal Ion Binding
4 Iron, 4 Sulfur Cluster Binding
Biological Process
Maturation Of SSU-rRNA From Tricistronic RRNA Transcript (SSU-rRNA, 5.8S RRNA, LSU-rRNA)
DNA Replication
DNA Replication, Synthesis Of RNA Primer
DNA Repair
Cellular Response To DNA Damage Stimulus
DNA Duplex Unwinding
Regulation Of DNA Double-strand Break Processing
Negative Regulation Of Double-strand Break Repair Via Homologous Recombination
G1/S Transition Of Mitotic Cell Cycle
Regulation Of Transcription Involved In G1/S Transition Of Mitotic Cell Cycle
DNA Synthesis Involved In DNA Repair
DNA Replication
DNA Replication, Synthesis Of RNA Primer
DNA Replication Initiation
DNA Strand Elongation Involved In DNA Replication
Leading Strand Elongation
Lagging Strand Elongation
DNA Repair
Nucleotide-excision Repair
Double-strand Break Repair Via Nonhomologous End Joining
Viral Process
Telomere Maintenance Via Semi-conservative Replication
Regulation Of Type I Interferon Production
Mitotic DNA Replication Initiation
DNA Synthesis Involved In UV-damage Excision Repair
Pathways
Inhibition of replication initiation of damaged DNA by RB1/E2F1
Polymerase switching on the C-strand of the telomere
Telomere C-strand synthesis initiation
DNA replication initiation
Activation of the pre-replicative complex
Polymerase switching
Removal of the Flap Intermediate
Processive synthesis on the lagging strand
G1/S-Specific Transcription
Drugs
Cladribine
Clofarabine
Fludarabine
Nelarabine
Diseases
GWAS
Basophil count (
32888494
)
Basophil percentage of white cells (
32888494
)
Menopause (age at onset) (
26414677
)
White blood cell count (basophil) (
29403010
27863252
)
Mean platelet volume (
32888494
)
Platelet count (
32888494
)
Interacting Genes
3 interacting genes:
POLA1
POLA2
RPA1
20 interacting genes:
CCNA2
CCNB1
CDC45
CDK1
CDK2
CDK2AP1
GINS4
HELB
PARP1
POLA2
POLE
PRIM2
RAD51
RB1
RBMS1
SERPINA3
SMC1A
SUMO2
TP53
XRCC5
Entrez ID
92797
5422
HPRD ID
09979
02416
Ensembl ID
ENSG00000127311
ENSG00000101868
Uniprot IDs
Q8NG08
A6NMQ1
P09884
PDB IDs
1K0P
1K18
1N5G
4Q5V
4QCL
4Y97
5EXR
5IUD
6AS7
Enriched GO Terms of Interacting Partners
?
Tagcloud
?
Tagcloud (Difference)
?
Tagcloud (Intersection)
?