DCLK1 and EFHC2

Data Source:
BioGRID (two hybrid)

		DCLK1	EFHC2
Description		doublecortin like kinase 1	EF-hand domain containing 2
Image
GO Annotations	Cellular Component	Integral Component Of Plasma Membrane Postsynaptic Density	Microtubule Axoneme Ciliary Basal Body Mitotic Spindle
	Molecular Function	Protein Kinase Activity ATP Binding Protein Serine Kinase Activity Protein Threonine Kinase Activity	Calcium Ion Binding Protein Binding Alpha-tubulin Binding
	Biological Process	Neuron Migration Protein Phosphorylation Nervous System Development Central Nervous System Development Response To Virus Endosomal Transport Peptidyl-serine Phosphorylation Central Nervous System Projection Neuron Axonogenesis Forebrain Development Intracellular Signal Transduction Axon Extension Neuron Projection Morphogenesis Dendrite Morphogenesis Negative Regulation Of Protein Localization To Nucleus	Mitotic Cytokinesis Mitotic Spindle Organization Regulation Of Neuron Projection Development Cilium-dependent Cell Motility Cellular Response To Leukemia Inhibitory Factor
Pathways
Drugs		Fostamatinib
Diseases
GWAS		Familial squamous cell lung carcinoma ( 29924316) Gut microbiota (bacterial taxa, hurdle binary method) ( 32572223) Height ( 21998595) Interleukin-10 levels ( 22205395) Obesity-related traits ( 23251661) Optic cup area ( 25631615 31798171 28073927) Pediatric non-alcoholic fatty liver disease activity score ( 23535911) Post bronchodilator FEV1 ( 26634245) Vertical cup-disc ratio ( 20548946 31798171) Vertical cup-disc ratio (adjusted for vertical disc diameter) ( 31959993) Vertical cup-disc ratio (multi-trait analysis) ( 31959993)	Mean arterial pressure ( 29403010)
Interacting Genes		3 interacting genes: APP CDC23 EFHC2	100 interacting genes: AASDHPPT ARHGEF5 ARMC7 CABP2 CACNB4 CARD9 CCDC102B CCDC120 CCDC13 CCDC57 CCHCR1 CCNG2 CDKN2A CLIC3 COPE CPNE2 CPNE7 CYFIP1 DCLK1 DDX6 DGCR6 DRC7 EDC3 EFHC1 EGLN3 EMD ENKD1 ESRRG EXOC8 EXOSC5 FAM107A FAM124B FAM214B FAM221B FBXL19 GEM GLYCTK GOLGA1 GPKOW GRB2 GYS1 HDAC4 HGS HNRNPLL INPP5J JAKMIP2 KANK2 KCTD7 KIF9 L3MBTL2 LMNB2 LMO2 LNX1 LONRF1 MAGOHB MAPK9 MID2 MISP MYLIP MYO5B NCDN NCK2 NDOR1 NEK6 NFKBID NME7 NR3C1 PBLD PHF1 PIBF1 PICK1 PLOD3 POLR1C PRPF18 PTK6 QARS1 RAD51D RCOR3 RECK RHOBTB3 RUNX1T1 SNRNP25 SOGA1 SPATA18 SPG21 STK16 TBC1D1 TBC1D22B TEKT4 TRIM42 TRIM50 TSSK3 TUBGCP4 TXK U2AF1 U2AF1L5 USP2 ZBTB16 ZFHX3 ZZZ3
Entrez ID		9201	80258
HPRD ID		09202	06540
Ensembl ID		ENSG00000133083	ENSG00000183690
Uniprot IDs		B7Z5K4 O15075 Q5VZY9	Q5JST6
PDB IDs		1MFW 1MG4 1UF0 5JZJ 5JZN 6KYQ 6KYR	2Z13 2Z14
Enriched GO Terms of Interacting Partners?
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