YTHDC1 and ADAMTS4

Data Source:
BioGRID (two hybrid)

		YTHDC1	ADAMTS4
Description		YTH domain containing 1	ADAM metallopeptidase with thrombospondin type 1 motif 4
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GO Annotations	Cellular Component	Nucleus Nucleoplasm Plasma Membrane Nuclear Speck	Extracellular Region Extracellular Space Nuclear Speck Extracellular Matrix Collagen-containing Extracellular Matrix
	Molecular Function	RNA Binding MRNA Binding Protein Binding N6-methyladenosine-containing RNA Binding	Protease Binding Metalloendopeptidase Activity Protein Binding Peptidase Activity Metallopeptidase Activity Metal Ion Binding
	Biological Process	Regulation Of Alternative MRNA Splicing, Via Spliceosome MRNA Splicing, Via Spliceosome MRNA Splice Site Selection MRNA Export From Nucleus Dosage Compensation By Inactivation Of X Chromosome Posttranscriptional Regulation Of Gene Expression Regulation Of MRNA Splicing, Via Spliceosome	Skeletal System Development Proteolysis Extracellular Matrix Disassembly Extracellular Matrix Organization
Pathways			Degradation of the extracellular matrix Degradation of the extracellular matrix Defective B3GALTL causes Peters-plus syndrome (PpS) O-glycosylation of TSR domain-containing proteins
Drugs
Diseases
GWAS		Mean corpuscular hemoglobin ( 32888494) Obesity-related traits ( 23251661)	Alzheimer's disease or family history of Alzheimer's disease ( 30617256) Asthma ( 31361310 27182965 31619474) Eosinophil counts ( 32888494) Eosinophil percentage of white cells ( 32888494) Family history of Alzheimer's disease ( 30617256) HDL cholesterol levels ( 32203549) Monocyte percentage of white cells ( 32888494 27863252)
Interacting Genes		42 interacting genes: ABL1 ADAMTS4 ANKRD28 CFH CLK1 CLK2 CORO1A DVL3 EDC4 EMD FYN GOLGA2 HNRNPK KHDRBS1 KHDRBS2 KHDRBS3 KRT18 KRTAP10-6 LAMC3 LAMTOR5 LZTS2 MPRIP PHF19 PICK1 PLG PROSER2 RBMY1A1 RBMY1F RBMY1J RNPS1 SDCBP2 SEPTIN10 SOX13 SRC SRPK1 SRPK2 SRSF1 SRSF2 TRA2A TRA2B TXK VPS51	11 interacting genes: ACAN BCAN FN1 FURIN HP MT2A SERPINA1 SERPINA3 SRPX2 YTHDC1 ZBTB16
Entrez ID		91746	9507
HPRD ID		11689	04853
Ensembl ID		ENSG00000083896	ENSG00000158859
Uniprot IDs		J3QR07 Q96MU7	O75173
PDB IDs		2YUD 4R3H 4R3I 6RT4 6RT5 6RT6 6RT7 6SYZ 6SZ1 6SZ2 6SZ3 6SZL 6SZN 6SZR 6SZT 6SZX 6SZY 6T01 6T02 6T03 6T04 6T05 6T06 6T07 6T08 6T09 6T0A 6T0C 6T0D 6T0O 6T0X 6T0Z 6T10 6T11 6T12 6WE8 6WE9 6WEA 6YKE 6YKI 6YKJ 6YKZ 6YL0 6YL8 6YL9 6YNI 6YNJ 6YNK 6YNL 6YNM 6YNN 6YNO 6YNP 6YOQ 6ZCM 6ZCN 6ZD9	2RJP 3B2Z 4WK7 4WKE 4WKI
Enriched GO Terms of Interacting Partners?
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