DGKI and RAB5C

Data Source:
BioGRID (affinity chromatography technology)

		DGKI	RAB5C
Description		diacylglycerol kinase iota	RAB5C, member RAS oncogene family
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus Cytoplasm Cytosol Plasma Membrane Postsynaptic Density Axon Synaptic Vesicle Membrane Protein-containing Complex Dendritic Spine Synapse Synaptic Membrane	Lysosomal Membrane Endosome Early Endosome Lipid Droplet Plasma Membrane Endomembrane System Endocytic Vesicle Early Endosome Membrane Azurophil Granule Membrane Melanosome Extracellular Exosome
	Molecular Function	NAD+ Kinase Activity Diacylglycerol Kinase Activity Protein Binding ATP Binding Metal Ion Binding	GTPase Activity Protein Binding GTP Binding GDP Binding
	Biological Process	Protein Kinase C-activating G Protein-coupled Receptor Signaling Pathway Platelet Activation Intracellular Signal Transduction Diacylglycerol Metabolic Process Lipid Phosphorylation Regulation Of Synaptic Transmission, Glutamatergic	Intracellular Protein Transport Endocytosis Regulation Of Endocytosis Neutrophil Degranulation Plasma Membrane To Endosome Transport
Pathways		Effects of PIP2 hydrolysis	Golgi Associated Vesicle Biogenesis Neutrophil degranulation TBC/RABGAPs Clathrin-mediated endocytosis RAB geranylgeranylation RAB GEFs exchange GTP for GDP on RABs
Drugs		alpha-Tocopherol succinate
Diseases
GWAS		Adult body size ( 32376654) Adventurousness ( 30643258) AIDS progression ( 21502085) anorexia nervosa, attention-deficit/hyperactivity disorder, autism spectrum disorder, bipolar disorder, major depression, obsessive-compulsive disorder, schizophrenia, or Tourette syndrome (pleiotropy) ( 31835028) Autism spectrum disorder or schizophrenia ( 28540026) Body mass index ( 26865924) Brain morphology (MOSTest) ( 32665545) Cognitive decline (age-related) ( 24468470) General risk tolerance (MTAG) ( 30643258) Lean body mass ( 28552196) Schizophrenia ( 28991256 25056061 29483656 30285260) Subcortical volume (MOSTest) ( 32665545) Testosterone levels in polycystic ovary syndrome ( 26284813)	Coronary artery disease ( 29212778) Fibrinogen levels ( 28107422 26561523) Mean corpuscular volume ( 32888494) Medication use (thyroid preparations) ( 31015401) Vitiligo ( 27723757) vWF and FVIII levels ( 30586737) White blood cell count ( 32888494)
Interacting Genes		1 interacting genes: VHL	15 interacting genes: ALS2CL APP APPL2 EEA1 ERBB2 GLP1R HRAS INCA1 RABAC1 RBSN RIN2 RIN3 SGSM3 TBC1D15 TBC1D17
Entrez ID		9162	5878
HPRD ID		07238	04947
Ensembl ID		ENSG00000157680	ENSG00000108774
Uniprot IDs		E7EWQ4 E9PFX6 O75912 Q59GE2	A0A024R1U4 P51148
PDB IDs			4KYI
Enriched GO Terms of Interacting Partners?
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