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CD3E and POLR1G
Data Source:
BioGRID
(affinity chromatography technology, pull down)
HPRD
(in vitro, in vivo)
CD3E
POLR1G
Description
CD3e molecule
RNA polymerase I subunit G
Image
No pdb structure
GO Annotations
Cellular Component
Immunological Synapse
Endoplasmic Reticulum
Plasma Membrane
Integral Component Of Plasma Membrane
Cell-cell Junction
External Side Of Plasma Membrane
T Cell Receptor Complex
Alpha-beta T Cell Receptor Complex
Dendritic Spine
Cell Body
RNA Polymerase I Transcription Regulator Complex
Fibrillar Center
Nucleoplasm
Chromosome
Nucleolus
RNA Polymerase I Complex
Mitochondrion
Cytosol
Molecular Function
Transmembrane Signaling Receptor Activity
Protein Binding
SH3 Domain Binding
Protein Kinase Binding
Signaling Receptor Complex Adaptor Activity
T Cell Receptor Binding
Identical Protein Binding
Protein Heterodimerization Activity
RNA Binding
DNA-directed 5'-3' RNA Polymerase Activity
Biological Process
Positive Regulation Of Cell-matrix Adhesion
Adaptive Immune Response
Positive Regulation Of T Cell Anergy
Cell Surface Receptor Signaling Pathway
Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway
Signal Complex Assembly
G Protein-coupled Receptor Signaling Pathway
Response To Nutrient
Positive Regulation Of Gene Expression
Negative Regulation Of Gene Expression
Dendrite Development
Cerebellum Development
T Cell Costimulation
Positive Regulation Of Interferon-gamma Production
Positive Regulation Of Interleukin-2 Production
Positive Regulation Of Interleukin-4 Production
Positive Regulation Of Cell-cell Adhesion Mediated By Integrin
Positive Regulation Of T Cell Proliferation
T Cell Activation
Regulation Of Apoptotic Process
Positive Thymic T Cell Selection
Negative Thymic T Cell Selection
Negative Regulation Of Smoothened Signaling Pathway
Positive Regulation Of Alpha-beta T Cell Proliferation
Positive Regulation Of Peptidyl-tyrosine Phosphorylation
Regulation Of Immune Response
Positive Regulation Of Calcium-mediated Signaling
T Cell Receptor Signaling Pathway
Protein-containing Complex Assembly
Apoptotic Signaling Pathway
Transcription Initiation From RNA Polymerase I Promoter
Transcription Elongation From RNA Polymerase I Promoter
Termination Of RNA Polymerase I Transcription
Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway
RRNA Transcription
Positive Regulation Of Gene Expression, Epigenetic
Pathways
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
Downstream TCR signaling
Phosphorylation of CD3 and TCR zeta chains
Translocation of ZAP-70 to Immunological synapse
Generation of second messenger molecules
PD-1 signaling
NoRC negatively regulates rRNA expression
B-WICH complex positively regulates rRNA expression
RNA Polymerase I Transcription Initiation
RNA Polymerase I Transcription Initiation
RNA Polymerase I Promoter Escape
RNA Polymerase I Transcription Termination
Drugs
Muromonab
Catumaxomab
Diseases
T-B+Severe combined immunodeficiencies (SCIDs), including the following eight diseases: X-linked SCID; Janus kinase-3 (Jak3) deficiency; IL-7 receptor alpha (IL7R alpha) deficiency; IL-2 receptor alpha (IL2R alpha) deficiency; CD45 deficiency; CD3 deficiency; Winged Helix Nude (WHN) deficiency; Immunodeficiency with thynoma
GWAS
Lung cancer in ever smokers (
28604730
)
Pulse pressure (
27841878
)
Interacting Genes
26 interacting genes:
ADAM33
BNIP3
CD3D
CD3G
CD79B
CSK
EPS8L1
LCK
MUC15
NCK1
NCK2
NCL
PIK3R1
PKMYT1
POLR1G
PTPN22
SHC1
SNTA1
SYK
TOP2B
TRAT1
TRB
UBASH3A
UNC119
ZAP70
ZFPL1
8 interacting genes:
CD3E
NCL
NFKBIB
POLR1C
POLR1D
POLR1E
TAF1A
UBTF
Entrez ID
916
10849
HPRD ID
08923
00125
Ensembl ID
ENSG00000198851
ENSG00000117877
Uniprot IDs
P07766
O15446
PDB IDs
1A81
1SY6
1XIW
2ROL
5QU2
6JXR
Enriched GO Terms of Interacting Partners
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Tagcloud (Intersection)
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