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FIBP and FGF1
Data Source:
HPRD
(in vitro, two hybrid)
FIBP
FGF1
Description
FGF1 intracellular binding protein
fibroblast growth factor 1
Image
No pdb structure
GO Annotations
Cellular Component
Nucleus
Mitochondrion
Endomembrane System
Membrane
Nuclear Speck
Extracellular Region
Extracellular Space
Nucleus
Nucleoplasm
Nucleolus
Cytoplasm
Cytosol
Cell Cortex
Extracellular Matrix
Molecular Function
Fibroblast Growth Factor Binding
Fibroblast Growth Factor Receptor Binding
Integrin Binding
Protein Binding
Growth Factor Activity
Heparin Binding
Hsp70 Protein Binding
S100 Protein Binding
Biological Process
Fibroblast Growth Factor Receptor Signaling Pathway
Platelet Aggregation
MAPK Cascade
Activation Of MAPK Activity
Angiogenesis
Organ Induction
Positive Regulation Of Protein Phosphorylation
Signal Transduction
Multicellular Organism Development
Positive Regulation Of Cell Population Proliferation
Fibroblast Growth Factor Receptor Signaling Pathway
Anatomical Structure Morphogenesis
Animal Organ Morphogenesis
Positive Regulation Of Endothelial Cell Migration
Positive Regulation Of Gene Expression
Cell Differentiation
Lung Development
Regulation Of Cell Migration
Positive Regulation Of Cell Migration
Activation Of Protein Kinase B Activity
Cellular Response To Heat
Wound Healing
Positive Regulation Of MAP Kinase Activity
Positive Regulation Of Cholesterol Biosynthetic Process
Positive Regulation Of Angiogenesis
Positive Regulation Of Transcription By RNA Polymerase II
Positive Regulation Of Epithelial Cell Proliferation
Positive Regulation Of Cell Division
Positive Regulation Of Protein Kinase B Signaling
Branch Elongation Involved In Ureteric Bud Branching
Mesonephric Epithelium Development
Regulation Of Endothelial Tube Morphogenesis
Positive Regulation Of Intracellular Signal Transduction
Positive Regulation Of Sprouting Angiogenesis
Positive Regulation Of Hepatocyte Proliferation
Regulation Of Endothelial Cell Chemotaxis To Fibroblast Growth Factor
Pathways
PI3K Cascade
PIP3 activates AKT signaling
Signaling by activated point mutants of FGFR1
Signaling by activated point mutants of FGFR3
FGFR4 ligand binding and activation
FGFR1b ligand binding and activation
FGFR3b ligand binding and activation
FGFR3c ligand binding and activation
FGFR1c ligand binding and activation
FGFR2c ligand binding and activation
FGFR2b ligand binding and activation
FGFR3 mutant receptor activation
Activated point mutants of FGFR2
Constitutive Signaling by Aberrant PI3K in Cancer
Phospholipase C-mediated cascade: FGFR1
Phospholipase C-mediated cascade; FGFR2
Phospholipase C-mediated cascade; FGFR3
Phospholipase C-mediated cascade; FGFR4
Downstream signaling of activated FGFR1
SHC-mediated cascade:FGFR1
PI-3K cascade:FGFR1
FRS-mediated FGFR1 signaling
PI-3K cascade:FGFR2
SHC-mediated cascade:FGFR2
FRS-mediated FGFR2 signaling
SHC-mediated cascade:FGFR3
FRS-mediated FGFR3 signaling
PI-3K cascade:FGFR3
FRS-mediated FGFR4 signaling
SHC-mediated cascade:FGFR4
PI-3K cascade:FGFR4
Negative regulation of FGFR1 signaling
Negative regulation of FGFR2 signaling
Negative regulation of FGFR3 signaling
Negative regulation of FGFR4 signaling
Signaling by FGFR2 in disease
Signaling by FGFR1 in disease
RAF/MAP kinase cascade
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling
Signaling by FGFR2 IIIa TM
Signaling by FGFR3 point mutants in cancer
Drugs
Pentosan polysulfate
Amlexanox
Heparin
Sucrosofate
Formic acid
O2-Sulfo-Glucuronic Acid
N,O6-Disulfo-Glucosamine
Naphthalene Trisulfonate
Pazopanib
5-aminonaphthalene-2-sulfonic acid
Foreskin fibroblast (neonatal)
Foreskin keratinocyte (neonatal)
Diseases
GWAS
Acne (severe) (
24927181
)
Asthma (
31959851
)
Chronic inflammatory diseases (ankylosing spondylitis, Crohn's disease, psoriasis, primary sclerosing cholangitis, ulcerative colitis) (pleiotropy) (
26974007
)
Psoriasis (
28537254
)
Cardiac hypertrophy (
21348951
)
Central corneal thickness (
32528159
29760442
)
Coronary artery disease (
33020668
)
Erosive tooth wear (severe vs non-severe) (
29898447
)
Erosive tooth wear (severe vs none or mild) (
29898447
)
Pre-treatment viral load in HIV-1 infection (
31219150
)
Waist-hip ratio (
31217584
)
Interacting Genes
9 interacting genes:
APP
CSNK2A1
CSNK2B
DAPK1
FGF1
FGFBP1
GSK3B
RNF32
TENM1
16 interacting genes:
CSNK2A1
CSNK2A2
CSNK2B
FGFBP1
FGFR1
FGFR2
FGFR3
FGFR4
FIBP
HSPA9
NRP1
PTX3
RPS2
S100A13
SYT1
VBP1
Entrez ID
9158
2246
HPRD ID
08492
00567
Ensembl ID
ENSG00000172500
ENSG00000113578
Uniprot IDs
O43427
A8K147
P05230
Q16089
PDB IDs
1AXM
1DJS
1DZC
1DZD
1E0O
1EVT
1HKN
1JQZ
1JT3
1JT4
1JT5
1JT7
1JTC
1JY0
1K5U
1K5V
1M16
1NZK
1P63
1PZZ
1Q03
1Q04
1QCT
1RG8
1RML
1RY7
1YTO
1Z2V
1Z4S
2AFG
2AQZ
2AXM
2ERM
2HW9
2HWA
2HWM
2HZ9
2K43
2K4A
2K8R
2KI4
2KI6
2NTD
2Q9X
2RQ9
3B9U
3BA4
3BA5
3BA7
3BAD
3BAG
3BAH
3BAO
3BAQ
3BAU
3BAV
3BB2
3CQA
3CRG
3CRH
3CRI
3CU1
3FGM
3FJ8
3FJ9
3FJA
3FJB
3FJC
3FJD
3FJE
3FJF
3FJH
3FJI
3FJJ
3FJK
3HOM
3JUT
3K1X
3O3Q
3OJ2
3OJM
3OJV
3UD7
3UD8
3UD9
3UDA
4J23
4Q91
4Q9G
4Q9P
4QAL
4QBC
4QBV
4QC4
4QO3
4XKI
4YOL
Enriched GO Terms of Interacting Partners
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Tagcloud (Intersection)
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