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CTDP1 and E2F1
Data Source:
HPRD
(in vitro)
CTDP1
E2F1
Description
CTD phosphatase subunit 1
E2F transcription factor 1
Image
GO Annotations
Cellular Component
Spindle Pole
Nucleus
Nucleoplasm
Cytoplasm
Centrosome
Spindle
Midbody
Protein-containing Complex
Intracellular Membrane-bounded Organelle
Spindle Midzone
Chromatin
Nucleus
Nucleoplasm
Mitochondrion
Centrosome
Protein-containing Complex
Rb-E2F Complex
RNA Polymerase II Transcription Regulator Complex
Molecular Function
TFIIF-class Transcription Factor Complex Binding
Phosphoprotein Phosphatase Activity
Protein Binding
RNA Polymerase II CTD Heptapeptide Repeat Phosphatase Activity
Tat Protein Binding
Protein Serine Phosphatase Activity
Protein Threonine Phosphatase Activity
RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding
DNA-binding Transcription Factor Activity, RNA Polymerase II-specific
Cis-regulatory Region Sequence-specific DNA Binding
DNA-binding Transcription Activator Activity
DNA Binding
DNA-binding Transcription Factor Activity
Protein Binding
Transcription Factor Binding
Protein Kinase Binding
Sequence-specific DNA Binding
Protein Dimerization Activity
Sequence-specific Double-stranded DNA Binding
Biological Process
Transcription By RNA Polymerase II
Transcription Elongation From RNA Polymerase II Promoter
Protein Dephosphorylation
Exit From Mitosis
Positive Regulation By Host Of Viral Transcription
Positive Regulation Of Viral Transcription
Cell Division
Negative Regulation Of Cell Growth Involved In Cardiac Muscle Cell Development
Dephosphorylation Of RNA Polymerase II C-terminal Domain
DNA Damage Checkpoint
G1/S Transition Of Mitotic Cell Cycle
Regulation Of Transcription Involved In G1/S Transition Of Mitotic Cell Cycle
Negative Regulation Of Transcription By RNA Polymerase II
Transcription, DNA-templated
Regulation Of Transcription, DNA-templated
Regulation Of Transcription By RNA Polymerase II
DNA Damage Response, Signal Transduction By P53 Class Mediator Resulting In Cell Cycle Arrest
Spermatogenesis
Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage
Positive Regulation Of Gene Expression
Viral Process
Forebrain Development
Positive Regulation Of Apoptotic Process
Anoikis
Negative Regulation Of DNA Binding
Negative Regulation Of Fat Cell Differentiation
Negative Regulation Of Transcription, DNA-templated
Positive Regulation Of Transcription, DNA-templated
Positive Regulation Of Transcription By RNA Polymerase II
Positive Regulation Of Fibroblast Proliferation
MRNA Stabilization
Positive Regulation Of Glial Cell Proliferation
Negative Regulation Of G0 To G1 Transition
Negative Regulation Of Fat Cell Proliferation
Cellular Response To Fatty Acid
Cellular Response To Hypoxia
Cellular Response To Xenobiotic Stimulus
Negative Regulation Of Transcription Involved In G1/S Transition Of Mitotic Cell Cycle
Intrinsic Apoptotic Signaling Pathway By P53 Class Mediator
Positive Regulation Of Protein Insertion Into Mitochondrial Membrane Involved In Apoptotic Signaling Pathway
Lens Fiber Cell Apoptotic Process
Cellular Response To Nerve Growth Factor Stimulus
Regulation Of G1/S Transition Of Mitotic Cell Cycle
Pathways
Formation of RNA Pol II elongation complex
Formation of the Early Elongation Complex
Formation of HIV elongation complex in the absence of HIV Tat
Formation of the HIV-1 Early Elongation Complex
Formation of HIV-1 elongation complex containing HIV-1 Tat
Formation of HIV-1 elongation complex containing HIV-1 Tat
Pausing and recovery of Tat-mediated HIV elongation
Abortive elongation of HIV-1 transcript in the absence of Tat
Tat-mediated HIV elongation arrest and recovery
Tat-mediated elongation of the HIV-1 transcript
HIV elongation arrest and recovery
Pausing and recovery of HIV elongation
RNA Polymerase II Pre-transcription Events
TP53 Regulates Transcription of DNA Repair Genes
RNA Polymerase II Transcription Elongation
Activation of NOXA and translocation to mitochondria
Inhibition of replication initiation of damaged DNA by RB1/E2F1
Transcription of E2F targets under negative control by DREAM complex
Transcription of E2F targets under negative control by DREAM complex
Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL2) in complex with HDAC1
Activation of PUMA and translocation to mitochondria
Pre-NOTCH Transcription and Translation
Pre-NOTCH Transcription and Translation
Oxidative Stress Induced Senescence
Oncogene Induced Senescence
TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest
CDC6 association with the ORC:origin complex
G2 Phase
Cyclin E associated events during G1/S transition
G1/S-Specific Transcription
G1/S-Specific Transcription
Cyclin D associated events in G1
Cyclin A:Cdk2-associated events at S phase entry
Transcriptional Regulation by E2F6
Transcriptional regulation of granulopoiesis
Transcriptional regulation of granulopoiesis
Defective binding of RB1 mutants to E2F1,(E2F2, E2F3)
Drugs
Diseases
GWAS
Adverse response to drug (
30420678
)
Cerebrospinal P-tau181p levels (
28247064
)
Metabolite levels (
23823483
)
Monocyte count (
27863252
)
Monocyte percentage of white cells (
32888494
)
Schizophrenia (
23212062
)
Smoking initiation (ever regular vs never regular) (
30679032
)
Heel bone mineral density (
30598549
)
Height (
31562340
)
Interacting Genes
40 interacting genes:
CDK7
CDK8
CDK9
CSNK2A1
CSNK2A2
CSNK2B
E2F1
ELP2
ELP3
ERH
GTF2F1
INTS1
INTS3
INTS6
INTS7
INTS8
MED1
MED14
MED15
MED16
MED17
MED23
MED24
MED25
MED26
MED4
MED6
MED7
MED8
NDRG2
POLR2A
POLR2B
PRKDC
PRMT5
SNRNP70
SNRPB
STK38
TCEA1
UPP1
WDR77
82 interacting genes:
ARID3A
ATAD2
ATM
ATR
BIN1
BIRC2
BRCA1
BRD2
BRMS1
BTRC
CCNA1
CCNA2
CDK1
CDK2
CDK3
CDK7
CDKN2A
CEBPE
CHEK2
CREBBP
CTDP1
CUL1
CUL2
DDB2
DIABLO
E2F6
EP300
ERCC3
FHL2
GSK3B
GTF2H1
HCFC1
IGF1
KAT5
KDM1A
MDM2
MDM4
MGA
MNAT1
MTA1
MYBL2
NCOA3
NCOA6
NCOR2
NDN
NFKB1
NPDC1
NRIP1
NSMCE3
PARP1
PHB
PKIB
PRDM2
PURA
RARA
RB1
RBL1
RNF126
RNF144A
SERTAD2
SETD7
SIRT1
SKP2
SP1
SP2
SP3
SP4
SPIB
STAT1
STOML1
TBP
TEAD3
TFDP1
TFDP2
TOPBP1
TP53
TP53BP1
TRRAP
UBE3A
UCHL5
VHL
YWHAQ
Entrez ID
9150
1869
HPRD ID
05377
01806
Ensembl ID
ENSG00000060069
ENSG00000101412
Uniprot IDs
A0A0A0MR03
Q9Y5B0
Q01094
Q9BSD8
PDB IDs
1J2X
1ONV
2K7L
1H24
1O9K
2AZE
5M9N
5M9O
6G0P
6ULS
Enriched GO Terms of Interacting Partners
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