ATP23 and ATG5

Data Source:
BioGRID (two hybrid)

		ATP23	ATG5
Description		ATP23 metallopeptidase and ATP synthase assembly factor homolog	autophagy related 5
Image		No pdb structure
GO Annotations	Cellular Component	Cytosol Plasma Membrane DNA-dependent Protein Kinase-DNA Ligase 4 Complex Cell Junction Extrinsic Component Of Mitochondrial Inner Membrane Intracellular Membrane-bounded Organelle	Cytoplasm Autophagosome Cytosol Axoneme Membrane Phagocytic Vesicle Membrane Phagophore Assembly Site Membrane Atg12-Atg5-Atg16 Complex Mitochondria-associated Endoplasmic Reticulum Membrane
	Molecular Function	Metalloendopeptidase Activity DNA-dependent Protein Kinase Activity Protein Binding Metal Ion Binding	Protein Binding
	Biological Process	Double-strand Break Repair Via Nonhomologous End Joining Protein Phosphorylation Mitochondrial Proton-transporting ATP Synthase Complex Assembly Mitochondrial Protein Processing	Autophagosome Assembly Autophagy Of Mitochondrion Blood Vessel Remodeling Regulation Of Cytokine Production Involved In Immune Response C-terminal Protein Lipidation Autophagy Apoptotic Process Cellular Response To Nitrogen Starvation Response To Fungus Macroautophagy Antigen Processing And Presentation Of Endogenous Antigen Negative Regulation Of Protein Ubiquitination Aggrephagy Negative Stranded Viral RNA Replication Vasodilation Response To Drug Negative Regulation Of Apoptotic Process Post-translational Protein Modification Autophagy Of Nucleus Negative Thymic T Cell Selection Otolith Development Negative Regulation Of Phagocytosis Regulation Of Release Of Sequestered Calcium Ion Into Cytosol Ventricular Cardiac Muscle Cell Development Heart Contraction Negative Regulation Of Cell Death Protein Lipidation Involved In Autophagosome Assembly Positive Regulation Of Mucus Secretion Cellular Response To Nitrosative Stress Positive Regulation By Symbiont Of Host Autophagy Regulation Of Cilium Assembly Negative Regulation Of Reactive Oxygen Species Metabolic Process Negative Regulation Of Histone H4-K16 Acetylation
Pathways			Macroautophagy Macroautophagy PINK1-PRKN Mediated Mitophagy Receptor Mediated Mitophagy Negative regulators of DDX58/IFIH1 signaling
Drugs
Diseases
GWAS			Allergic disease (asthma, hay fever or eczema) ( 29083406) Asthma ( 30929738 32296059) Asthma (childhood onset) ( 30929738) Asthma onset (childhood vs adult) ( 30929738) Eosinophil counts ( 32888494) Eosinophil percentage of white cells ( 32888494) Glucose homeostasis traits ( 25524916) Limited cutaneous systemic scleroderma ( 24387989) Monobrow ( 27182965) Multiple myeloma ( 27363682) Rheumatoid arthritis ( 30423114 24390342) Systemic lupus erythematosus ( 27399966 23273568 26502338 28714469 19838193) Systemic lupus erythematosus and Systemic sclerosis ( 23740937) Systemic lupus erythematosus or rheumatoid arthritis ( 27193031) Systemic sclerosis ( 24387989 31672989) Visceral fat ( 30942860) Youthful appearance (self-reported) ( 32339537)
Interacting Genes		31 interacting genes: ABI2 ACTN3 AP2B1 ATG5 BAG4 BCL6 C1orf109 CCDC120 CSTF2 CSTF2T CTNNA3 DUSP21 EXOC8 FOXH1 FOXI1 FRS3 GLYCTK GUCD1 HNRNPF HOXA1 HR KLC3 KRTAP10-1 MGAT5B PLSCR4 PPP1R16A STK16 TRIP6 TSSK3 XRCC6 ZIC1	28 interacting genes: ATG10 ATG12 ATG16L1 ATG16L2 ATP23 CALCOCO2 CAPN1 CAPN2 CCDC12 CCHCR1 FADD FMR1 GRIPAP1 HOOK2 INCA1 IRGM KEAP1 KIAA1328 MAD1L1 MEOX2 OPTN PSMB11 RAB33B RACK1 TECPR1 TEKT4 VCP WDFY3
Entrez ID		91419	9474
HPRD ID		17256	16051
Ensembl ID		ENSG00000166896	ENSG00000057663
Uniprot IDs		Q9Y6H3	A9UGY9 Q7Z3H3 Q9H1Y0
PDB IDs			4GDK 4GDL 4NAW 4TQ0 4TQ1 5D7G 5NPV 5NPW
Enriched GO Terms of Interacting Partners?
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