MTMR4 and HIPK3

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid)

		MTMR4	HIPK3
Description		myotubularin related protein 4	homeodomain interacting protein kinase 3
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Extracellular Space Cytoplasm Endosome Cytosol Membrane Early Endosome Membrane	Nucleus Cytoplasm Cytosol Plasma Membrane Nuclear Body PML Body
	Molecular Function	Phosphatidylinositol-3-phosphatase Activity Protein Serine/threonine Phosphatase Activity Protein Tyrosine Phosphatase Activity Protein Binding Protein Phosphatase Binding Metal Ion Binding Phosphatidylinositol-3,5-bisphosphate 3-phosphatase Activity	Protein Kinase Activity Protein Serine/threonine Kinase Activity Protein Tyrosine Kinase Activity ATP Binding Protein Serine Kinase Activity Protein Threonine Kinase Activity
	Biological Process	Protein Dephosphorylation Phosphatidylinositol Biosynthetic Process Transforming Growth Factor Beta Receptor Signaling Pathway Regulation Of Autophagy Response To Denervation Involved In Regulation Of Muscle Adaptation Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Peptidyl-tyrosine Dephosphorylation Phosphatidylinositol Dephosphorylation Regulation Of Phosphatidylinositol Dephosphorylation	Protein Phosphorylation Apoptotic Process MRNA Transcription Peptidyl-serine Phosphorylation Peptidyl-threonine Phosphorylation Peptidyl-tyrosine Phosphorylation Negative Regulation Of Apoptotic Process Negative Regulation Of JUN Kinase Activity
Pathways		Synthesis of PIPs at the early endosome membrane Synthesis of PIPs at the late endosome membrane Downregulation of TGF-beta receptor signaling
Drugs			Fostamatinib
Diseases
GWAS		Cognitive function ( 25644384) Refractive error ( 32231278) Vitamin D levels ( 25208829)	Anger ( 24489884) Obese vs. thin ( 30677029) Vertical cup-disc ratio (adjusted for vertical disc diameter) ( 31959993) Vertical cup-disc ratio (multi-trait analysis) ( 31959993)
Interacting Genes		2 interacting genes: HIPK3 NEDD4	37 interacting genes: AR ARRB2 C1QA CREB1 CREBBP DAXX FADD FAS FLNC GLUL GORASP1 GRB2 HEYL HNRNPA1 HNRNPA2B1 HNRNPH1 LIMD1 LIMK2 LIMS2 MBD1 MTMR4 NR2F2 RGS3 SIAH1 SIAH2 SKIL SNIP1 SRSF1 SRSF5 SUMO1 TGFB1I1 TOX4 TP73 TRA2B UBE2I ZNF107 ZYX
Entrez ID		9110	10114
HPRD ID		11945	05111
Ensembl ID		ENSG00000108389	ENSG00000110422
Uniprot IDs		Q9NYA4	A8KAE4 Q9H422
PDB IDs
Enriched GO Terms of Interacting Partners?
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