MPZL1 and EXOSC4

Data Source:
HPRD (two hybrid)

		MPZL1	EXOSC4
Description		myelin protein zero like 1	exosome component 4
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GO Annotations	Cellular Component	Integral Component Of Plasma Membrane Focal Adhesion Cell Surface	Nuclear Exosome (RNase Complex) Cytoplasmic Exosome (RNase Complex) Exosome (RNase Complex) Nucleus Nucleoplasm Nucleolus Cytoplasm Cytosol Transcriptionally Active Chromatin Intracellular Membrane-bounded Organelle
	Molecular Function	Structural Molecule Activity Protein Binding	3'-5'-exoribonuclease Activity Exoribonuclease Activity Protein Binding MRNA 3'-UTR AU-rich Region Binding
	Biological Process	Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Cell-cell Signaling	Maturation Of 5.8S RRNA Nuclear-transcribed MRNA Catabolic Process RRNA Processing RRNA Catabolic Process Positive Regulation Of Cell Growth Nuclear-transcribed MRNA Catabolic Process, Exonucleolytic, 3'-5' U4 SnRNA 3'-end Processing Regulation Of MRNA Stability Exonucleolytic Catabolism Of Deadenylated MRNA DNA Deamination Defense Response To Virus Nuclear MRNA Surveillance Histone MRNA Catabolic Process Polyadenylation-dependent SnoRNA 3'-end Processing RNA Phosphodiester Bond Hydrolysis, Exonucleolytic
Pathways			ATF4 activates genes in response to endoplasmic reticulum stress mRNA decay by 3' to 5' exoribonuclease Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA KSRP (KHSRP) binds and destabilizes mRNA Major pathway of rRNA processing in the nucleolus and cytosol
Drugs
Diseases
GWAS		Alzheimer's disease (late onset) ( 22881374) Post bronchodilator FEV1/FVC ratio in COPD ( 26634245)	Asthma ( 31959851) Bipolar disorder ( 31043756) Bipolar I disorder ( 31043756)
Interacting Genes		10 interacting genes: DOK7 EXOSC4 FBXO7 FHL3 MFF PTPN11 SRC STAT3 TRIM55 TRIM63	33 interacting genes: AKR1A1 DIS3 DXO EEF1A1 EXOSC1 EXOSC10 EXOSC2 EXOSC3 EXOSC6 EXOSC7 EXOSC8 EXOSC9 FAHD1 GADD45GIP1 GTF2IRD1 HBS1L HNRNPD LNX1 LRRC8D MPZL1 MTREX NEK1 PALS2 POLE2 PPARA PTEN SDCBP SKIV2L SMPD4 TSEN15 UPF1 UPF2 UPF3B
Entrez ID		9019	54512
HPRD ID		05086	16221
Ensembl ID		ENSG00000197965	ENSG00000178896
Uniprot IDs		A0A024R8Y3 A8K5D4 O95297	Q9NPD3
PDB IDs		6IGO 6IGT 6IGW	2NN6 6D6Q 6D6R 6H25
Enriched GO Terms of Interacting Partners?
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