LACRT and SDC1

Data Source:
HPRD (in vitro)

		LACRT	SDC1
Description		lacritin	syndecan 1
Image		No pdb structure
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Secretory Granule	Golgi Lumen Plasma Membrane Integral Component Of Plasma Membrane External Side Of Plasma Membrane Cell Surface Protein-containing Complex Lysosomal Lumen Extracellular Exosome
	Molecular Function	Fibronectin Binding Protein Binding Collagen Binding Growth Factor Activity Laminin-1 Binding Protein N-terminus Binding	Protein Binding Protein C-terminus Binding Identical Protein Binding
	Biological Process	Protein Acetylation Positive Regulation Of Cell Population Proliferation Epithelial Structure Maintenance Positive Regulation Of Macroautophagy Calcium-mediated Signaling Negative Regulation Of Lipopolysaccharide-mediated Signaling Pathway Calcineurin-NFAT Signaling Cascade Protein Localization To Golgi Apparatus Defense Response To Bacterium Negative Regulation Of Apoptotic Process Positive Regulation Of Epithelial Cell Proliferation Positive Regulation Of Peptidyl-tyrosine Phosphorylation Positive Regulation Of Calcium-mediated Signaling Positive Regulation Of Secretion Positive Regulation Of Release Of Sequestered Calcium Ion Into Cytosol Positive Regulation Of Epithelial Cell Proliferation Involved In Wound Healing Tear Secretion Positive Regulation Of Calcineurin-NFAT Signaling Cascade	Retinoid Metabolic Process Ureteric Bud Development Glycosaminoglycan Biosynthetic Process Glycosaminoglycan Catabolic Process Inflammatory Response Response To Toxic Substance Cell Migration Cytokine-mediated Signaling Pathway Wound Healing Odontogenesis Response To Hydrogen Peroxide Myoblast Development Leukocyte Migration Response To Glucocorticoid Response To CAMP Response To Calcium Ion Striated Muscle Cell Development Sertoli Cell Development Canonical Wnt Signaling Pathway Positive Regulation Of Exosomal Secretion Positive Regulation Of Extracellular Exosome Assembly
Pathways			A tetrasaccharide linker sequence is required for GAG synthesis HS-GAG biosynthesis HS-GAG biosynthesis HS-GAG degradation Cell surface interactions at the vascular wall Syndecan interactions Syndecan interactions Defective B4GALT7 causes EDS, progeroid type Defective B3GAT3 causes JDSSDHD Defective EXT2 causes exostoses 2 Defective EXT1 causes exostoses 1, TRPS2 and CHDS Defective B3GALT6 causes EDSP2 and SEMDJL1 Other interleukin signaling Retinoid metabolism and transport
Drugs
Diseases
GWAS			Alanine aminotransferase levels in non-alcoholic fatty liver disease ( 31311600) Amyotrophic lateral sclerosis (sporadic) ( 24529757) Apolipoprotein A1 levels ( 32203549) Body mass index ( 28892062) HDL cholesterol levels ( 32203549) LDL cholesterol levels ( 32203549) Seasonality ( 25562672) Triglyceride levels ( 32203549)
Interacting Genes		6 interacting genes: APP FN1 NID1 SDC1 TGM2 VTN	16 interacting genes: APP CASK CCL5 CD63 CTSG CXCL8 ELANE FGF2 HGF IGFBP7 LACRT MDK MMP14 PTEN PTN SDCBP
Entrez ID		90070	6382
HPRD ID		06302	01718
Ensembl ID		ENSG00000135413	ENSG00000115884
Uniprot IDs		Q9GZZ8	P18827
PDB IDs			4GVC 4GVD 6EJE
Enriched GO Terms of Interacting Partners?
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