CCNG1 and GAK

Data Source:
HPRD (in vivo, in vitro)

		CCNG1	GAK
Description		cyclin G1	cyclin G associated kinase
Image		No pdb structure
GO Annotations	Cellular Component	Cyclin-dependent Protein Kinase Holoenzyme Complex Nucleus Nucleoplasm Cytoplasm	Cytoplasm Golgi Apparatus Cytosol Focal Adhesion Membrane Vesicle Intracellular Membrane-bounded Organelle Perinuclear Region Of Cytoplasm Presynapse
	Molecular Function	Protein Binding Cyclin-dependent Protein Serine/threonine Kinase Regulator Activity	Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Clathrin Binding Cyclin Binding Chaperone Binding Protein Serine Kinase Activity Protein Threonine Kinase Activity
	Biological Process	Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity Mitotic Cell Cycle Phase Transition Cell Division	Protein Phosphorylation Receptor-mediated Endocytosis Endoplasmic Reticulum Organization Golgi Organization Cell Cycle Negative Regulation Of Neuron Projection Development Synaptic Vesicle Uncoating Protein Localization To Golgi Apparatus Chaperone Cofactor-dependent Protein Refolding Membrane Organization Clathrin Coat Disassembly Clathrin-dependent Endocytosis Protein Localization To Plasma Membrane Golgi To Lysosome Transport Clathrin-coated Pit Assembly
Pathways		Regulation of TP53 Degradation	Golgi Associated Vesicle Biogenesis Clathrin-mediated endocytosis
Drugs			Fostamatinib
Diseases
GWAS		HIV progression (CD4 and viral load) ( 28132517) Metabolite levels ( 31628463) Plasma anti-thyroglobulin levels ( 29678681) Severe influenza A (H1N1) infection ( 26379185)	HDL cholesterol ( 30275531) Mortality in sepsis ( 27639821) Parkinson's disease ( 20711177 21292315 25064009 27182965 22438815 21738487 32310270) Parkinson's disease (age of onset) ( 30957308) Parkinson's disease (familial) ( 18985386) Parkinson's disease or first degree relation to individual with Parkinson's disease ( 31701892) Primary biliary cholangitis ( 26394269) Triglycerides ( 30275531)
Interacting Genes		28 interacting genes: APP CBY2 CCDC125 CDK5 CDKN2A GAK GAS8 GRN HMBOX1 KRT40 KRTAP10-7 LMNA LTBP3 LZTS2 MDM2 MT-CO2 NFATC4 PAK5 PLEKHA4 PNMA1 PPP2CA PTPA RBPMS SHKBP1 TFAP2C TFIP11 TNIP1 TP53	14 interacting genes: AP1M1 AP1M2 AP2M1 APP AR AXIN1 CCNG1 CDK5 CLTC CREBBP HSPA8 LRRK1 MFHAS1 USO1
Entrez ID		900	2580
HPRD ID		03345	03631
Ensembl ID		ENSG00000113328	ENSG00000178950
Uniprot IDs		P51959	B4DS37 O14976
PDB IDs			4C57 4C58 4C59 4O38 4Y8D 5Y7Z 5Y80
Enriched GO Terms of Interacting Partners?
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