KSR1 and BRAP

Data Source:
BioGRID (pull down, affinity chromatography technology)

		KSR1	BRAP
Description		kinase suppressor of ras 1	BRCA1 associated protein
Image			No pdb structure
GO Annotations	Cellular Component	Cytoplasm Endoplasmic Reticulum Endoplasmic Reticulum Membrane Cytosol Membrane Ruffle Membrane Protein-containing Complex	Ubiquitin Ligase Complex Nucleoplasm Cytoplasm Cytosol Nuclear Membrane
	Molecular Function	Protein Kinase Activity MAP-kinase Scaffold Activity Protein Binding ATP Binding Protein C-terminus Binding Metal Ion Binding 14-3-3 Protein Binding Protein Serine Kinase Activity Protein Threonine Kinase Activity	Nucleic Acid Binding Ubiquitin-protein Transferase Activity Protein Binding Nuclear Localization Sequence Binding Zinc Ion Binding Identical Protein Binding Ubiquitin Protein Ligase Activity
	Biological Process	MAPK Cascade Activation Of MAPKKK Activity Protein Phosphorylation Signal Transduction Ras Protein Signal Transduction CAMP-mediated Signaling Regulation Of Cell Population Proliferation Regulation Of MAP Kinase Activity Positive Regulation Of MAPK Cascade	MAPK Cascade Ras Protein Signal Transduction Negative Regulation Of Signal Transduction Protein Ubiquitination
Pathways		RAF activation MAP2K and MAPK activation Negative regulation of MAPK pathway Signaling by moderate kinase activity BRAF mutants Signaling by high-kinase activity BRAF mutants Signaling by BRAF and RAF fusions Paradoxical activation of RAF signaling by kinase inactive BRAF Signaling downstream of RAS mutants Signaling by RAF1 mutants	RAF activation Negative regulation of MAPK pathway Signaling by moderate kinase activity BRAF mutants Paradoxical activation of RAF signaling by kinase inactive BRAF Signaling downstream of RAS mutants
Drugs
Diseases
GWAS		Chronic inflammatory diseases (ankylosing spondylitis, Crohn's disease, psoriasis, primary sclerosing cholangitis, ulcerative colitis) (pleiotropy) ( 26974007) Crohn's disease ( 28067908) Monocyte count ( 27863252) Monocyte percentage of white cells ( 32888494 27863252) Systemic lupus erythematosus ( 28714469)	Alcohol consumption (max-drinks) ( 29460428) Alcohol dependence ( 31591379) Alcohol dependence symptom count ( 29460428) Alcohol use disorder (consumption score) ( 30940813) Asthma ( 30929738 32296059) Asthma (age of onset) ( 31036433) Asthma (childhood onset) ( 31036433 30929738) Asthma onset (childhood vs adult) ( 30929738) Blood protein levels ( 29875488) Body mass index ( 26426971 25673413) C-reactive protein levels or LDL-cholesterol levels (pleiotropy) ( 27286809) Cholesterol, total ( 24097068 20686565) Coffee consumption ( 29367735) Colorectal cancer ( 26151821) Crohn's disease ( 28067908) Diastolic blood pressure x alcohol consumption (light vs heavy) interaction (2df test) ( 29912962) Diastolic blood pressure x alcohol consumption interaction (2df test) ( 29912962) Drinking behavior ( 21372407) Esophageal cancer ( 19698717) Gastroesophageal reflux disease ( 31527586) Hematological and biochemical traits ( 20139978) High light scatter reticulocyte count ( 32888494) High light scatter reticulocyte percentage of red cells ( 32888494) Hypothyroidism ( 22493691) Inflammatory bowel disease ( 28067908) LDL cholesterol ( 24097068 20686565) Mean arterial pressure x alcohol consumption (light vs heavy) interaction (2df test) ( 29912962) Mean arterial pressure x alcohol consumption interaction (2df test) ( 29912962) Mean reticulocyte volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Myocardial infarction ( 30226566) Parental lifespan ( 30642433) Platelet count ( 27863252) Plateletcrit ( 27863252) Primary biliary cirrhosis ( 22961000) Psoriasis ( 25854761 28537254) Response to alcohol consumption (flushing response) ( 29460428) Reticulocyte count ( 32888494) Reticulocyte fraction of red cells ( 32888494) Serum folate levels ( 29953918) Serum uric acid levels ( 29124443) Small vessel stroke (CCSp classification) ( 32047268) Systolic blood pressure x alcohol consumption interaction (2df test) ( 29912962) Tumor necrosis factor levels ( 32805626)
Interacting Genes		10 interacting genes: BRAP EPHB2 MAP2K1 MAPK1 MARK3 NME1 PJA2 RAF1 UBE2L3 YWHAZ	41 interacting genes: AKAP3 APOA1 ATMIN BRCA1 BRK1 CCDC105 CCDC30 CDC14A CENPF CNKSR1 DDB1 DNMT1 FAM184A FBXO2 HMG20A HRAS KSR1 LINC00852 NUMA1 PHLPP1 RBM12 SHCBP1L SKP2 SMARCE1 SYNE2 TANC2 TEX35 TRIM41 TRIM55 TRIM8 UBB UBC UBE2D2 UBE2H UBE2L3 USP15 USP4 YJU2 ZNF382 ZNF479 ZNF521
Entrez ID		8844	8315
HPRD ID		18980	05405
Ensembl ID		ENSG00000141068	ENSG00000089234
Uniprot IDs		Q8IVT5	Q59H81 Q7Z569
PDB IDs		5VYK 7JUW 7JUX 7JUY 7JUZ 7JV0 7JV1
Enriched GO Terms of Interacting Partners?
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