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FGF18 and LYAR
Data Source:
BioGRID
(two hybrid)
FGF18
LYAR
Description
fibroblast growth factor 18
Ly1 antibody reactive
Image
GO Annotations
Cellular Component
Extracellular Region
Extracellular Space
Nucleolus
Cytoplasm
Photoreceptor Outer Segment
Nucleus
Nucleoplasm
Nucleolus
Cytoplasm
Molecular Function
Fibroblast Growth Factor Receptor Binding
Type 1 Fibroblast Growth Factor Receptor Binding
Type 2 Fibroblast Growth Factor Receptor Binding
Growth Factor Activity
DNA Binding
RNA Binding
Protein Binding
Activating Transcription Factor Binding
Identical Protein Binding
Metal Ion Binding
Transcription Regulator Inhibitor Activity
Biological Process
MAPK Cascade
Angiogenesis
Positive Regulation Of Protein Phosphorylation
Regulation Of Endothelial Cell Proliferation
Intramembranous Ossification
Endochondral Ossification
Chondrocyte Development
Signal Transduction
Cell-cell Signaling
Positive Regulation Of Cell Population Proliferation
Fibroblast Growth Factor Receptor Signaling Pathway
Anatomical Structure Morphogenesis
Animal Organ Morphogenesis
Positive Regulation Of Gene Expression
Cell Differentiation
Lung Development
Regulation Of Cell Migration
Positive Regulation Of Vascular Endothelial Growth Factor Receptor Signaling Pathway
Positive Regulation Of Chondrocyte Differentiation
Positive Regulation Of MAP Kinase Activity
Positive Regulation Of Blood Vessel Endothelial Cell Migration
Positive Regulation Of Angiogenesis
Positive Regulation Of Protein Kinase B Signaling
Positive Regulation Of ERK1 And ERK2 Cascade
Regulation Of Sprouting Angiogenesis
Positive Regulation Of Endothelial Cell Chemotaxis To Fibroblast Growth Factor
Negative Regulation Of Transcription By RNA Polymerase II
RRNA Processing
Innate Immune Response
Negative Regulation Of Innate Immune Response
Positive Regulation Of Transcription By RNA Polymerase I
Erythrocyte Development
Positive Regulation Of Phagocytosis
Pathways
PI3K Cascade
PIP3 activates AKT signaling
Signaling by activated point mutants of FGFR3
FGFR4 ligand binding and activation
FGFR3b ligand binding and activation
FGFR3c ligand binding and activation
FGFR2c ligand binding and activation
FGFR3 mutant receptor activation
Activated point mutants of FGFR2
Constitutive Signaling by Aberrant PI3K in Cancer
Phospholipase C-mediated cascade; FGFR2
Phospholipase C-mediated cascade; FGFR3
Phospholipase C-mediated cascade; FGFR4
PI-3K cascade:FGFR2
SHC-mediated cascade:FGFR2
FRS-mediated FGFR2 signaling
SHC-mediated cascade:FGFR3
FRS-mediated FGFR3 signaling
PI-3K cascade:FGFR3
FRS-mediated FGFR4 signaling
SHC-mediated cascade:FGFR4
PI-3K cascade:FGFR4
Negative regulation of FGFR2 signaling
Negative regulation of FGFR3 signaling
Negative regulation of FGFR4 signaling
Signaling by FGFR2 in disease
FGFRL1 modulation of FGFR1 signaling
RAF/MAP kinase cascade
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling
Signaling by FGFR3 point mutants in cancer
Drugs
Diseases
GWAS
Brain morphology (MOSTest) (
32665545
)
Chronic obstructive pulmonary disease (
30804561
)
FEV1 (
30804560
)
Gut microbiota (bacterial taxa, hurdle binary method) (
32572223
)
Height (
28552196
25282103
31562340
)
Lung function (FEV1/FVC) (
30804560
)
Peak expiratory flow (
30804560
)
PR interval (
32439900
)
Subcortical volume (MOSTest) (
32665545
)
Disease progression in age-related macular degeneration (
29346644
)
Interacting Genes
6 interacting genes:
FGFR1
FGFR2
FGFR3
FGFR4
LYAR
PTX3
12 interacting genes:
ADSS1
BEND7
CD2
FGF18
PHF20L1
PRKRA
SDCBP2
SREK1IP1
TERF1
TERF2
ZBTB16
ZHX1
Entrez ID
8817
55646
HPRD ID
04766
10064
Ensembl ID
ENSG00000156427
ENSG00000145220
Uniprot IDs
O76093
Q9NX58
PDB IDs
4CJM
6ZMI
6ZMO
6ZVH
Enriched GO Terms of Interacting Partners
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Tagcloud
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Tagcloud (Difference)
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Tagcloud (Intersection)
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