IL18R1 and IL37

Data Source:
HPRD (in vitro)

		IL18R1	IL37
Description		interleukin 18 receptor 1	interleukin 37
Image
GO Annotations	Cellular Component	Plasma Membrane Interleukin-18 Receptor Complex	Extracellular Region Extracellular Space Nucleoplasm Cytosol Intracellular Membrane-bounded Organelle
	Molecular Function	Interleukin-1 Receptor Activity Protein Binding Signaling Receptor Activity Interleukin-18 Binding Interleukin-18 Receptor Activity NAD(P)+ Nucleosidase Activity NAD+ Nucleotidase, Cyclic ADP-ribose Generating	Cytokine Activity Interleukin-1 Receptor Binding Protein Binding
	Biological Process	Inflammatory Response Immune Response Signal Transduction Natural Killer Cell Activation Positive Regulation Of Interferon-gamma Production Interleukin-18-mediated Signaling Pathway T-helper 1 Cell Differentiation Positive Regulation Of NF-kappaB Transcription Factor Activity Cellular Response To Cytokine Stimulus Negative Regulation Of Cold-induced Thermogenesis Positive Regulation Of NIK/NF-kappaB Signaling Positive Regulation Of T-helper 1 Cell Cytokine Production	Inflammatory Response To Antigenic Stimulus Inflammatory Response Immune Response Positive Regulation Of Gene Expression Cytokine-mediated Signaling Pathway Negative Regulation Of Interleukin-6 Production Negative Regulation Of Tumor Necrosis Factor Production Regulation Of Inflammatory Response Cellular Response To Lipopolysaccharide Cellular Response To Cytokine Stimulus
Pathways		Interleukin-37 signaling Interleukin-18 signaling	Interleukin-37 signaling Interleukin-18 signaling
Drugs
Diseases
GWAS		Acute anterior uveitis (with or without ankylosing spondylitis) ( 25200001) Allergic disease (asthma, hay fever and/or eczema) (age of onset) ( 32603359) Allergic disease (asthma, hay fever and/or eczema) (multivariate analysis) ( 32603359) Allergic disease (asthma, hay fever or eczema) ( 29083406 29785011) Allergic rhinitis ( 31361310) Allergic sensitization ( 23817571) Asthma ( 23028483 31361310 31959851 30929738 20860503 31619474 26620591 29273806 22561531) Asthma (adult onset) ( 31036433 30929738) Asthma (childhood onset) ( 31036433 30929738 29273806) Asthma onset (childhood vs adult) ( 30929738) Asthma or allergic disease (pleiotropy) ( 29785011) Atopic dermatitis ( 23042114 26482879) Atypical femoral fracture in phosphonate treatment ( 31006051) Bisphosphonate-associated atypical femoral fracture ( 31006051) Blood protein levels ( 30072576 29875488 28240269) Celiac disease ( 20190752 18311140) Chronic inflammatory diseases (ankylosing spondylitis, Crohn's disease, psoriasis, primary sclerosing cholangitis, ulcerative colitis) (pleiotropy) ( 26974007) Crohn's disease ( 28067908 21102463) Delirium ( 29631748) Eczema ( 31361310) Eosinophil counts ( 32888494 27863252) Eosinophil percentage of granulocytes ( 27863252) Eosinophil percentage of white cells ( 32888494 27863252) Inflammatory bowel disease ( 28067908 23128233) Leprosy ( 25642632) Mean spheric corpuscular volume ( 32888494) Medication use (adrenergics, inhalants) ( 31015401) Medication use (glucocorticoids) ( 31015401) Nasal polyps ( 30643255) Neutrophil percentage of granulocytes ( 27863252) Neutrophil percentage of white cells ( 32888494) Pediatric autoimmune diseases ( 26301688) Polymyositis ( 26362759) Primary biliary cholangitis ( 26394269) Sum eosinophil basophil counts ( 27863252)	Dysmenorrheic pain severity ( 29855537) Menstruation quality of life impact (dysmenorrhea) ( 29855537) Pain medicine use during menstruation ( 29855537) Pulmonary function ( 23932459) Response to anti-retroviral therapy (ddI/d4T) in HIV-1 infection (Grade 2 peripheral neuropathy) ( 24554482)
Interacting Genes		4 interacting genes: CD48 IL18 IL1RAP IL37	8 interacting genes: CASP1 CASP4 IL18BP IL18R1 PRKAB2 SMAD3 TRIM55 TRIM63
Entrez ID		8809	27178
HPRD ID		05138	05695
Ensembl ID		ENSG00000115604	ENSG00000125571
Uniprot IDs		Q13478	Q9NZH6
PDB IDs		3WO3 3WO4 4R6U	5HN1 6NCU
Enriched GO Terms of Interacting Partners?
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