TNFRSF10A and DAP3

Data Source:
HPRD (two hybrid, in vivo)

		TNFRSF10A	DAP3
Description		TNF receptor superfamily member 10a	death associated protein 3
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GO Annotations	Cellular Component	Golgi Apparatus Cytosol Plasma Membrane Cell Surface Integral Component Of Membrane Membrane Raft	Nucleoplasm Mitochondrion Mitochondrial Inner Membrane Mitochondrial Small Ribosomal Subunit
	Molecular Function	Protease Binding Death Receptor Activity Protein Binding Transcription Factor Binding Signaling Receptor Activity Identical Protein Binding TRAIL Binding	RNA Binding Structural Constituent Of Ribosome Protein Binding GTP Binding
	Biological Process	Apoptotic Process Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Signal Transduction Cell Surface Receptor Signaling Pathway Activation Of NF-kappaB-inducing Kinase Activity Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors TRAIL-activated Apoptotic Signaling Pathway Regulation Of Apoptotic Process Positive Regulation Of Apoptotic Process Leukocyte Migration Cellular Response To Mechanical Stimulus Extrinsic Apoptotic Signaling Pathway Regulation Of Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Negative Regulation Of Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors	Mitochondrial Translational Elongation Mitochondrial Translational Termination Apoptotic Signaling Pathway
Pathways		Caspase activation via Death Receptors in the presence of ligand Cell surface interactions at the vascular wall Regulation by c-FLIP RIPK1-mediated regulated necrosis CASP8 activity is inhibited TP53 Regulates Transcription of Death Receptors and Ligands Dimerization of procaspase-8 TRAIL signaling	Mitochondrial translation initiation Mitochondrial translation elongation Mitochondrial translation elongation Mitochondrial translation termination
Drugs
Diseases
GWAS		Advanced age-related macular degeneration ( 26691988) Age-related macular degeneration ( 21909106 23455636) Attention deficit hyperactivity disorder ( 20732625) Central serous retinopathy ( 31872073) Early age-related macular degeneration ( 32843070)	Body fat distribution (leg fat ratio) ( 30664634) Body fat distribution (trunk fat ratio) ( 30664634) Brain morphology (min-P) ( 32665545) Brain morphology (MOSTest) ( 32665545) Cortical surface area (min-P) ( 32665545) Cortical surface area (MOSTest) ( 32665545) Cortical thickness (min-P) ( 32665545) Cortical thickness (MOSTest) ( 32665545) Crohn's disease ( 28067908) Inflammatory bowel disease ( 28067908) Subcortical volume (min-P) ( 32665545) Subcortical volume (MOSTest) ( 32665545)
Interacting Genes		15 interacting genes: BCL10 BTK CASP8 CD4 COL2A1 DAP3 FADD MADD MOAP1 RASSF1 RIPK1 TNFRSF10B TNFRSF10D TNFSF10 TRADD	14 interacting genes: AHR AR ESR1 ESR2 FADD HIF1A HSP90AA1 NR3C1 PGR PPARA PTEN THRA TNFRSF10A TNFRSF25
Entrez ID		8797	7818
HPRD ID		04679	03646
Ensembl ID		ENSG00000104689	ENSG00000132676
Uniprot IDs		O00220	P51398
PDB IDs		5CIR	3J9M 6NU2 6NU3 6RW4 6RW5 6VLZ 6VMI 6ZS9 6ZSA 6ZSB 6ZSC 6ZSD 6ZSE 6ZSG
Enriched GO Terms of Interacting Partners?
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