ADAM18 and NDST1

Data Source:
BioGRID (two hybrid)

		ADAM18	NDST1
Description		ADAM metallopeptidase domain 18	N-deacetylase and N-sulfotransferase 1
Image		No pdb structure
GO Annotations	Cellular Component	Membrane Integral Component Of Membrane	Golgi Membrane Golgi Apparatus Integral Component Of Membrane
	Molecular Function	Metalloendopeptidase Activity Metallopeptidase Activity	Protein Binding [heparan Sulfate]-glucosamine N-sulfotransferase Activity Deacetylase Activity Heparan Sulfate N-deacetylase Activity
	Biological Process	Proteolysis Cell Adhesion Multicellular Organism Development Spermatogenesis Binding Of Sperm To Zona Pellucida Cell Differentiation	Cardiac Septum Development Glycosaminoglycan Biosynthetic Process Protein Sulfation Inflammatory Response Respiratory Gaseous Exchange By Respiratory System Cell Population Proliferation Fibroblast Growth Factor Receptor Signaling Pathway Heparan Sulfate Proteoglycan Biosynthetic Process, Polysaccharide Chain Biosynthetic Process Heparin Biosynthetic Process Forebrain Development Midbrain Development Aorta Development Positive Regulation Of MAPK Cascade Positive Regulation Of Smoothened Signaling Pathway Embryonic Neurocranium Morphogenesis Embryonic Viscerocranium Morphogenesis Coronary Vasculature Development
Pathways			HS-GAG biosynthesis
Drugs			Adenosine 3',5'-diphosphate
Diseases
GWAS		HIV-1 susceptibility ( 22174851) Visceral adipose tissue/subcutaneous adipose tissue ratio ( 26480920)	Blood protein levels ( 30072576) Cholangiocarcinoma in primary sclerosing cholangitis ( 28779025) Crohn's disease ( 28067908) Inflammatory bowel disease ( 28067908) Neutrophil count ( 32888494)
Interacting Genes
Entrez ID		8749	3340
HPRD ID		07469	02912
Ensembl ID		ENSG00000168619	ENSG00000070614
Uniprot IDs		Q0VAI3 Q9Y3Q7	A8K8T3 B7Z1Q0 E7EVJ3 P52848
PDB IDs			1NST
Enriched GO Terms of Interacting Partners?
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