ADAM23 and ICOS

Data Source:
BioGRID (affinity chromatography technology)

		ADAM23	ICOS
Description		ADAM metallopeptidase domain 23	inducible T cell costimulator
Image		No pdb structure
GO Annotations	Cellular Component	Extracellular Region Plasma Membrane Integral Component Of Plasma Membrane Glutamatergic Synapse Integral Component Of Presynaptic Membrane	Extracellular Region Plasma Membrane Integral Component Of Membrane
	Molecular Function	Metalloendopeptidase Activity Integrin Binding Protein Binding Metallopeptidase Activity	Protein Binding
	Biological Process	Proteolysis Cell Adhesion Central Nervous System Development Cellular Response To Leukemia Inhibitory Factor	T Cell Tolerance Induction Immune Response T Cell Costimulation Positive Regulation Of Protein Kinase B Signaling Cell-cell Adhesion
Pathways		LGI-ADAM interactions
Drugs
Diseases			Common variable immunodeficiency (CVID), including the following four diseases: Inducible T Cell costimulator (ICOS) defect; TACI defect; CD19 defect; BAFFR defect
GWAS		Bipolar disorder and schizophrenia ( 22688191) Blood protein levels ( 30072576 29875488) Body mass index ( 28892062 25673413) Childhood body mass index ( 26604143) Fish- and plant-related diet ( 32066663) Neurological blood protein biomarker levels ( 31320639) Tonsillectomy ( 27182965 28928442) Trunk fat mass ( 28552196) Waist-hip ratio ( 28552196)	Alopecia areata ( 20596022 25608926) Aluminium levels ( 26025379) Body mass index ( 28892062) Celiac disease ( 20190752) Diastolic blood pressure ( 30224653) Hypothyroidism ( 27182965) Idiopathic dilated cardiomyopathy ( 29495422) Inflammatory bowel disease ( 26192919) Metabolite levels ( 23823483) Obesity-related traits ( 23251661) Primary biliary cholangitis ( 28425483) Rheumatoid arthritis ( 23143596) Rheumatoid arthritis (ACPA-positive) ( 23143596) Ulcerative colitis ( 26192919)
Interacting Genes		1 interacting genes: PRNP	4 interacting genes: ICOSLG NUFIP2 RC3H1 WIF1
Entrez ID		8745	29851
HPRD ID		04752	09196
Ensembl ID		ENSG00000114948	ENSG00000163600
Uniprot IDs		A0A024R3W8 E7EWD3 O75077	Q53QY6 Q9Y6W8
PDB IDs			6X4G 7JOO
Enriched GO Terms of Interacting Partners?
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