CBR3 and ARIH2

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid)

		CBR3	ARIH2
Description		carbonyl reductase 3	ariadne RBR E3 ubiquitin protein ligase 2
Image			No pdb structure
GO Annotations	Cellular Component	Extracellular Space Nucleoplasm Cytosol	Ubiquitin Ligase Complex Nucleus Nucleoplasm Cytoplasm Cul5-RING Ubiquitin Ligase Complex
	Molecular Function	3-keto Sterol Reductase Activity Carbonyl Reductase (NADPH) Activity Protein Binding NADPH Binding	Ubiquitin-protein Transferase Activity Protein Binding Zinc Ion Binding Ubiquitin Conjugating Enzyme Binding Ubiquitin Protein Ligase Activity
	Biological Process	Xenobiotic Metabolic Process Phylloquinone Catabolic Process Cognition	Protein Polyubiquitination Ubiquitin-dependent Protein Catabolic Process Multicellular Organism Development Protein Ubiquitination Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Developmental Cell Growth Protein K63-linked Ubiquitination Protein K48-linked Ubiquitination Hematopoietic Stem Cell Proliferation Positive Regulation Of Protein Targeting To Mitochondrion
Pathways		Phase I - Functionalization of compounds	Antigen processing: Ubiquitination & Proteasome degradation
Drugs
Diseases
GWAS		Blood protein levels ( 30072576 29875488) Lumbar spine bone mineral density ( 22504420)	Blood protein levels ( 28240269) Body fat distribution (leg fat ratio) ( 30664634) Body fat distribution (trunk fat ratio) ( 30664634) Brain morphology (min-P) ( 32665545) Brain morphology (MOSTest) ( 32665545) Cortical surface area (MOSTest) ( 32665545) Crohn's disease ( 28067908) Hip circumference ( 28552196) Inflammatory bowel disease ( 28067908) Morning person ( 30696823) Refractive error ( 32231278) Subcortical volume (min-P) ( 32665545) Subcortical volume (MOSTest) ( 32665545) Sum eosinophil basophil counts ( 27863252) Systolic blood pressure ( 30224653) Ulcerative colitis ( 28067908)
Interacting Genes		5 interacting genes: ARIH2 BICD2 RAB35 SDCBP UBC	50 interacting genes: APOBEC3F APOBEC3G ARAP1 BUB1 CBR3 CCDC33 CEP126 CKB CRX DCUN1D1 DISC1 DLST EEF1A1 EEF1G EML4 ENSA IL4R KAT5 KCNQ2 MEOX2 NEDD8 PAX6 PHF7 PPP2R1A PTN REL RHEB RPL8 SCAMP2 SGCE SLC1A6 TP53 TRIM27 UBC UBE2D1 UBE2D2 UBE2D3 UBE2D4 UBE2E1 UBE2E2 UBE2E3 UBE2L3 UBE2L6 UBE2N UBE2R2 UBE2T UBE2V1 UGP2 UTP14A WDR91
Entrez ID		874	10425
HPRD ID		07222	09286
Ensembl ID		ENSG00000159231	ENSG00000177479
Uniprot IDs		O75828 V9HW40	O95376 Q53ET9 Q6IBL8
PDB IDs		2HRB
Enriched GO Terms of Interacting Partners?
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