TNFRSF25 and NPPB

Data Source:
BioGRID (affinity chromatography technology)

		TNFRSF25	NPPB
Description		TNF receptor superfamily member 25	natriuretic peptide B
Image
GO Annotations	Cellular Component	Extracellular Region Cytosol Plasma Membrane Integral Component Of Plasma Membrane	Extracellular Region Extracellular Space Nucleus Cytoplasm Protein-containing Complex
	Molecular Function	Tumor Necrosis Factor-activated Receptor Activity Signaling Receptor Activity	Signaling Receptor Binding Hormone Activity Protein Binding Diuretic Hormone Activity Hormone Receptor Binding
	Biological Process	Apoptotic Process Signal Transduction Cell Surface Receptor Signaling Pathway Tumor Necrosis Factor-mediated Signaling Pathway Regulation Of Apoptotic Process Apoptotic Signaling Pathway	Negative Regulation Of Systemic Arterial Blood Pressure CGMP Biosynthetic Process Protein Folding Cell Surface Receptor Signaling Pathway Receptor Guanylyl Cyclase Signaling Pathway Neuropeptide Signaling Pathway Body Fluid Secretion Regulation Of Blood Pressure Negative Regulation Of Angiogenesis CGMP-mediated Signaling Negative Regulation Of Cell Growth Positive Regulation Of Urine Volume Positive Regulation Of Renal Sodium Excretion Regulation Of Vascular Permeability Blood Vessel Diameter Maintenance
Pathways		TNFs bind their physiological receptors
Drugs			Carvedilol Oxymetholone
Diseases
GWAS			B-type natriuretic peptide levels ( 29237677 25561047) B-type natriuretic peptide to N-terminal pro B-type natriuretic peptide ratio ( 29237677) Blood pressure ( 21909110) Blood protein levels ( 30072576 29875488) Blood protein levels in cardiovascular risk ( 28369058) Diastolic blood pressure ( 28739976 27618452) Diastolic blood pressure (cigarette smoking interaction) ( 29455858) Diastolic blood pressure x alcohol consumption interaction (2df test) ( 29912962) Diastolic blood pressure x smoking status (current vs non-current) interaction (2df test) ( 29455858) Diastolic blood pressure x smoking status (ever vs never) interaction (2df test) ( 29455858) Mean arterial pressure x alcohol consumption interaction (2df test) ( 29912962) N-terminal pro B-type natriuretic peptide levels ( 29237677) NT-proBNP levels in acute coronary syndrome ( 26908625) Pulse pressure ( 30578418) Pulse pressure x alcohol consumption interaction (2df test) ( 29912962) Systolic blood pressure ( 19430483 28739976 27618447 27618452) Systolic blood pressure (cigarette smoking interaction) ( 29455858) Systolic blood pressure x smoking status (current vs non-current) interaction (2df test) ( 29455858) Systolic blood pressure x smoking status (ever vs never) interaction (2df test) ( 29455858) Tuberculosis ( 29036319)
Interacting Genes		8 interacting genes: BAG4 DAP3 MAPK1 TNFRSF1A TNFSF12 TNFSF15 TRADD TRAF2	13 interacting genes: CYSRT1 EWSR1 GEMIN4 HDAC4 KRT40 KRTAP10-3 KRTAP10-9 NOTCH2NLA NPR1 NPR2 NPR3 PSMA3 SERTAD3
Entrez ID		8718	4879
HPRD ID		04532	08974
Ensembl ID		ENSG00000215788	ENSG00000120937
Uniprot IDs		Q93038	P16860
PDB IDs		5YGP 5YGS	1YK1 3N56
Enriched GO Terms of Interacting Partners?
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