SERPINB7 and SLC5A2

Data Source:
HPRD (in vivo)

		SERPINB7	SLC5A2
Description		serpin family B member 7	solute carrier family 5 member 2
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Extracellular Space Cytoplasm	Plasma Membrane Integral Component Of Membrane Extracellular Exosome
	Molecular Function	Serine-type Endopeptidase Inhibitor Activity	Low-affinity Glucose:sodium Symporter Activity Glucose:sodium Symporter Activity Alpha-glucoside Transmembrane Transporter Activity D-glucose Transmembrane Transporter Activity
	Biological Process	Negative Regulation Of Endopeptidase Activity Positive Regulation Of Transforming Growth Factor Beta1 Production Positive Regulation Of Collagen Biosynthetic Process Positive Regulation Of Glomerular Mesangial Cell Proliferation Positive Regulation Of Platelet-derived Growth Factor Production	Alpha-glucoside Transport Carbohydrate Metabolic Process Sodium Ion Transport Hexose Transmembrane Transport Glucose Import Across Plasma Membrane Sodium Ion Import Across Plasma Membrane
Pathways			Cellular hexose transport Defective SLC5A2 causes renal glucosuria (GLYS1)
Drugs			Dapagliflozin Canagliflozin Empagliflozin Ertugliflozin
Diseases
GWAS		Allergic disease (asthma, hay fever and/or eczema) (age of onset) ( 32603359) Allergic disease (asthma, hay fever and/or eczema) (multivariate analysis) ( 32603359) Asthma ( 31361310 30929738 32296059 31619474) Asthma (age of onset) ( 31036433) Asthma (childhood onset) ( 31036433 30929738) Asthma onset (childhood vs adult) ( 30929738) Food allergy ( 29051540) Hen's egg allergy ( 29051540) Systolic blood pressure ( 29208002)	Glucosuria ( 30476138) Glucosuria (mild) ( 30476138) Glucosuria (moderate to severe) ( 30476138)
Interacting Genes			1 interacting genes: AQP2
Entrez ID		8710	6524
HPRD ID		04524	08919
Ensembl ID		ENSG00000166396	ENSG00000140675
Uniprot IDs		A8K3Q8 O75635	P31639
PDB IDs
Enriched GO Terms of Interacting Partners?
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