MARCO and SAP130

Data Source:
BioGRID (affinity chromatography technology)

		MARCO	SAP130
Description		macrophage receptor with collagenous structure	Sin3A associated protein 130
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Collagen Trimer Intracellular Anatomical Structure Cytoplasm Plasma Membrane Integral Component Of Plasma Membrane Endocytic Vesicle Membrane	Nuclear Speck Sin3-type Complex
	Molecular Function	Amyloid-beta Binding G Protein-coupled Receptor Binding Transmembrane Signaling Receptor Activity Scavenger Receptor Activity Cargo Receptor Activity Pattern Recognition Receptor Activity
	Biological Process	Positive Regulation Of Protein Phosphorylation Endocytosis Receptor-mediated Endocytosis Phagocytosis, Engulfment Cell Surface Receptor Signaling Pathway Adenylate Cyclase-inhibiting G Protein-coupled Receptor Signaling Pathway Apoptotic Cell Clearance Innate Immune Response Positive Regulation Of ERK1 And ERK2 Cascade Amyloid-beta Clearance	Negative Regulation Of Transcription By RNA Polymerase II
Pathways		Scavenging by Class A Receptors Scavenging by Class A Receptors	HATs acetylate histones NoRC negatively regulates rRNA expression
Drugs		Titanium dioxide Silicon dioxide
Diseases
GWAS		Lung function (FVC) ( 30061609) Medication use (adrenergics, inhalants) ( 31015401) Triglyceride levels ( 32203549)	Anti-saccade response ( 29064472) Gut microbiota (bacterial taxa, hurdle binary method) ( 32572223)
Interacting Genes		2 interacting genes: SCGB3A1 SCGB3A2	6 interacting genes: ARID4B CCR9 CUL2 GPS1 MYC SMAD3
Entrez ID		8685	79595
HPRD ID		05337	18015
Ensembl ID		ENSG00000019169	ENSG00000136715
Uniprot IDs		Q4ZG40 Q9UEW3	A0A2R8YDB8 H7BXF5 Q96DP1 Q9H0E3
PDB IDs
Enriched GO Terms of Interacting Partners?
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