CDC14B and DLC1

Data Source:
BioGRID (two hybrid)

		CDC14B	DLC1
Description		cell division cycle 14B	DLC1 Rho GTPase activating protein
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GO Annotations	Cellular Component	Spindle Pole Nucleus Nucleoplasm Nucleolus Cytoplasm Centrosome Mitotic Spindle	Nucleus Cytoplasm Cytosol Caveola Focal Adhesion Cortical Actin Cytoskeleton Ruffle Membrane Membrane Raft
	Molecular Function	Protein Serine/threonine Phosphatase Activity Protein Tyrosine Phosphatase Activity Protein Binding Protein Tyrosine/serine/threonine Phosphatase Activity Protein Serine Phosphatase Activity Protein Threonine Phosphatase Activity	GTPase Activator Activity Protein Binding Lipid Binding SH2 Domain Binding
	Biological Process	Microtubule Cytoskeleton Organization Mitotic Cell Cycle DNA Repair Protein Dephosphorylation Regulation Of Exit From Mitosis G2 DNA Damage Checkpoint Positive Regulation Of Cytokinesis Peptidyl-tyrosine Dephosphorylation Cilium Assembly Mitotic Cell Cycle Arrest Signal Transduction Involved In G2 DNA Damage Checkpoint Positive Regulation Of Ubiquitin Protein Ligase Activity	Neural Tube Closure Heart Morphogenesis Apoptotic Process Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Signal Transduction Negative Regulation Of Cell Population Proliferation Regulation Of Cell Shape Hindbrain Morphogenesis Actin Cytoskeleton Organization Negative Regulation Of Cell Migration Forebrain Development Regulation Of Actin Cytoskeleton Organization Regulation Of Rho Protein Signal Transduction Negative Regulation Of Rho Protein Signal Transduction Positive Regulation Of Protein Dephosphorylation Positive Regulation Of GTPase Activity Focal Adhesion Assembly Regulation Of Small GTPase Mediated Signal Transduction Negative Regulation Of Stress Fiber Assembly Negative Regulation Of Focal Adhesion Assembly Positive Regulation Of Execution Phase Of Apoptosis
Pathways		MAPK6/MAPK4 signaling	Rho GTPase cycle
Drugs
Diseases
GWAS		Cognitive ability ( 29186694) Cognitive ability (MTAG) ( 29186694) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Height ( 31562340) Household income ( 31844048) Intelligence (MTAG) ( 29326435) Peginterferon alfa-2a treatment response in chronic hepatitis B infection ( 30972912)	Apolipoprotein A1 levels ( 32203549) Attention deficit hyperactivity disorder ( 30563984) Bipolar disorder ( 22688191) Emphysema imaging phenotypes ( 26030696) Epstein-Barr virus copy number in lymphoblastoid cell lines ( 28654678) Erosive tooth wear (severe vs non-severe) ( 29898447) Erosive tooth wear (severe vs none or mild) ( 29898447) Familial hepatitis B virus-related hepatocellular carcinoma ( 28662289) Fractional exhaled nitric oxide (childhood) ( 24315451) Gestational age at birth (child effect) ( 31194736) Gut microbiota (bacterial taxa, rank normal transformation method) ( 32572223) Heel bone mineral density ( 30598549) Height ( 31562340) Intraocular pressure ( 29617998) Itch intensity from mosquito bite adjusted by bite size ( 28199695) Late-onset Alzheimer's disease ( 27770636) Lung adenocarcinoma ( 28604730) Metabolite levels ( 23823483) Nicotine dependence symptom count ( 25555482) Nose size ( 27182965) Obesity-related traits ( 23251661) Obstructive sleep apnea trait (apnea hypopnea index) ( 29077507) Percentage gas trapping ( 26030696) Platelet distribution width ( 32888494) PR interval ( 32439900) Refractive error ( 32231278) Smoking initiation (ever regular vs never regular) ( 31089300) Waist-hip ratio ( 28552196)
Interacting Genes		19 interacting genes: BCL10 BUB1 CCND1 CDKN2A DLC1 MCC MFAP1 MLH3 MSH2 MTDH PRKAB2 PSMB1 SIRT2 SKP2 SMAD4 SPANXN2 STK11 TP53 ZNF696	35 interacting genes: ACOT7 AKT1 AOPEP BAAT CCDC180 CDC14B CORO2A CTSV FANCC FBP2 HEMGN HSD17B3 MAPK3 PFKM PKM PPP3R2 PTEN RANGAP1 RASA1 RHOA RPS6KA1 SFRP4 SMAD1 STX17 TDRD7 TGFB1 TMEFF1 TMEM129 TMOD1 TNS2 TRMO USP4 XPA ZNF189 ZNF510
Entrez ID		8555	10395
HPRD ID		04615	05035
Ensembl ID		ENSG00000081377	ENSG00000164741
Uniprot IDs		O60729	A8K119 Q96QB1
PDB IDs		1OHC 1OHD 1OHE	2DKY 2GYT 2KAP 2LOZ 3KUQ 5FZT
Enriched GO Terms of Interacting Partners?
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