TSLP and CRLF2

Data Source:
HPRD (in vivo)

		TSLP	CRLF2
Description		thymic stromal lymphopoietin	cytokine receptor like factor 2
Image
GO Annotations	Cellular Component	Extracellular Region Extracellular Space	Extracellular Region Plasma Membrane External Side Of Plasma Membrane Integral Component Of Membrane Receptor Complex
	Molecular Function	Cytokine Activity Interleukin-7 Receptor Binding	Cytokine Receptor Activity Leukemia Inhibitory Factor Receptor Activity Oncostatin-M Receptor Activity Ciliary Neurotrophic Factor Receptor Binding Cytokine Binding
	Biological Process	Positive Regulation Of Cytokine-mediated Signaling Pathway Positive Regulation Of Cell Population Proliferation Positive Regulation Of Chemokine Production Positive Regulation Of Interleukin-10 Production Positive Regulation Of Interleukin-13 Production Positive Regulation Of Interleukin-5 Production Positive Regulation Of Interleukin-6 Production Positive Regulation Of Mast Cell Activation Interleukin-7-mediated Signaling Pathway Positive Regulation Of Tyrosine Phosphorylation Of STAT Protein Negative Regulation Of Apoptotic Process Positive Regulation Of Inflammatory Response Positive Regulation Of Chemokine (C-C Motif) Ligand 1 Production Positive Regulation Of Granulocyte Colony-stimulating Factor Production Positive Regulation Of Receptor Signaling Pathway Via STAT	Positive Regulation Of Cell Population Proliferation Cytokine-mediated Signaling Pathway Positive Regulation Of Interleukin-5 Production Positive Regulation Of Mast Cell Activation Interleukin-7-mediated Signaling Pathway Oncostatin-M-mediated Signaling Pathway Leukemia Inhibitory Factor Signaling Pathway Positive Regulation Of Receptor Signaling Pathway Via STAT
Pathways		Interleukin-7 signaling Interleukin-7 signaling	Interleukin-7 signaling Interleukin-7 signaling
Drugs
Diseases
GWAS		Allergic disease (asthma, hay fever and/or eczema) (age of onset) ( 32603359) Allergic disease (asthma, hay fever and/or eczema) (multivariate analysis) ( 32603359) Allergic disease (asthma, hay fever or eczema) ( 29083406 29785011) Allergic rhinitis ( 22036096) Allergic sensitization ( 23817571) Asthma ( 21804548 21804549 31361310 31959851 30929738 27611488 27182965 32296059 31619474 29785011 29273806) Asthma (adult onset) ( 31036433 30929738) Asthma (age of onset) ( 31036433) Asthma (childhood onset) ( 31036433 30929738) Asthma (moderate or severe) ( 30552067) Asthma and hay fever ( 24388013) Asthma onset (childhood vs adult) ( 30929738) Asthma or allergic disease (pleiotropy) ( 29785011) Eosinophil counts ( 19198610 32888494 27863252) Eosinophil percentage of granulocytes ( 27863252) Eosinophil percentage of white cells ( 32888494 27863252) Eosinophilic esophagitis ( 25017104 25407941) Eosinophilic granulomatosis with polyangiitis ( 31719529) Medication use (adrenergics, inhalants) ( 31015401) Medication use (glucocorticoids) ( 31015401) Nasal polyps ( 30643255) Neutrophil percentage of granulocytes ( 27863252) Self-reported allergy ( 23817569)
Interacting Genes		8 interacting genes: APP CRLF2 FBXO7 IKBKG IL7R PRNP STAT3 STAT5A	3 interacting genes: IL7R JAK2 TSLP
Entrez ID		85480	64109
HPRD ID		06108	02288
Ensembl ID		ENSG00000145777	ENSG00000205755
Uniprot IDs		Q969D9	D0E2W4 Q9HC73
PDB IDs		5J11 5J12 5J13	5J11 5J12
Enriched GO Terms of Interacting Partners?
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