NKD2 and TGFA

Data Source:
BioGRID (affinity chromatography technology)
HPRD (two hybrid, in vitro, in vivo)

		NKD2	TGFA
Description		NKD inhibitor of WNT signaling pathway 2	transforming growth factor alpha
Image		No pdb structure
GO Annotations	Cellular Component	Cytoplasm Plasma Membrane Basolateral Plasma Membrane Lateral Plasma Membrane Cytoplasmic Vesicle Exocytic Vesicle Cell Periphery	Golgi Membrane Extracellular Region Extracellular Space Endoplasmic Reticulum Membrane Plasma Membrane Cell Surface ER To Golgi Transport Vesicle Membrane Integral Component Of Membrane Basolateral Plasma Membrane Clathrin-coated Vesicle Membrane Cytoplasmic Vesicle Endoplasmic Reticulum-Golgi Intermediate Compartment Membrane Perinuclear Region Of Cytoplasm
	Molecular Function	Calcium Ion Binding Protein Binding Growth Factor Binding Ubiquitin Protein Ligase Binding Myosin Heavy Chain Binding ATPase Binding	Epidermal Growth Factor Receptor Binding Protein Binding Growth Factor Activity
	Biological Process	Exocytosis Positive Regulation Of Protein Processing Wnt Signaling Pathway Negative Regulation Of Wnt Signaling Pathway Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Golgi Vesicle Fusion To Target Membrane Protein Localization To Plasma Membrane Negative Regulation Of Canonical Wnt Signaling Pathway Positive Regulation Of Protein Localization To Plasma Membrane	MAPK Cascade Activation Of MAPK Activity Regulation Of Transcription By RNA Polymerase II Endoplasmic Reticulum To Golgi Vesicle-mediated Transport Signal Transduction Epidermal Growth Factor Receptor Signaling Pathway Positive Regulation Of Cell Population Proliferation Intracellular Signal Transduction Negative Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Positive Regulation Of Epidermal Growth Factor-activated Receptor Activity Positive Regulation Of Mitotic Nuclear Division COPII Vesicle Coating Positive Regulation Of Epithelial Cell Proliferation Positive Regulation Of Cell Division Positive Regulation Of Protein Kinase B Signaling Membrane Organization
Pathways			PIP3 activates AKT signaling Signaling by EGFR GRB2 events in EGFR signaling GAB1 signalosome SHC1 events in EGFR signaling EGFR downregulation COPII-mediated vesicle transport EGFR interacts with phospholipase C-gamma Constitutive Signaling by Aberrant PI3K in Cancer Inhibition of Signaling by Overexpressed EGFR RAF/MAP kinase cascade Cargo concentration in the ER PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling Cargo recognition for clathrin-mediated endocytosis Clathrin-mediated endocytosis TFAP2 (AP-2) family regulates transcription of growth factors and their receptors Extra-nuclear estrogen signaling Estrogen-dependent gene expression Estrogen-dependent nuclear events downstream of ESR-membrane signaling
Drugs
Diseases			Isolated orofacial clefts, including: Cleft lip with or without cleft palate; Cleft palate Gastric cancer
GWAS		Lung adenocarcinoma ( 28604730) Lung cancer ( 28604730) Lung cancer in ever smokers ( 28604730) Mean corpuscular hemoglobin concentration ( 32888494) Pancreatic cancer ( 25086665) QT interval ( 24952745) Red cell distribution width ( 32888494 27863252 28957414)	Acne (severe) ( 24927181) Cough in response to angiotensin-converting enzyme inhibitor drugs ( 28084903) Hair shape ( 29220522) Hand grip strength ( 29691431 29313844) Heel bone mineral density ( 30598549) Hip minimal joint space width ( 27701424) Longevity ( 20834067) Neutrophil count ( 21507922) Obesity-related traits ( 23251661) Osteoarthritis ( 30664745) Pulse pressure in young-onset hypertension ( 24892410) Response to citalopram or escitalopram in depression ( 27622933) Severe progression in rheumatoid arthritis ( 29065906) Superior frontal gyrus grey matter volume ( 25335168)
Interacting Genes		9 interacting genes: ANAPC11 CDKN1A FBXO7 FUS GRB2 LNX1 RCHY1 TGFA VDR	16 interacting genes: ADAM10 ADAM17 EGFR ELANE ERBB2 ERBB4 GORASP1 GORASP2 LEPROTL1 MAGI2 MAGI3 NKD2 RHBDF1 SDCBP SGTA SNTA1
Entrez ID		85409	7039
HPRD ID		08483	07522
Ensembl ID		ENSG00000145506	ENSG00000163235
Uniprot IDs		Q969F2	E7EPT6 F8VNR3 P01135
PDB IDs			1GK5 1MOX 1YUF 1YUG 2TGF 3E50 3TGF 4TGF 5KN5
Enriched GO Terms of Interacting Partners?
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