TMEM128 and SLC1A3

Data Source:
BioGRID (two hybrid)

		TMEM128	SLC1A3
Description		transmembrane protein 128	solute carrier family 1 member 3
Image		No pdb structure
GO Annotations	Cellular Component	Cellular_component Integral Component Of Membrane	Plasma Membrane Integral Component Of Plasma Membrane Basal Plasma Membrane Membrane Cytoplasmic Vesicle Neuron Projection Neuronal Cell Body Synapse Perinuclear Region Of Cytoplasm Membrane Protein Complex
	Molecular Function	Molecular_function Protein Binding	L-glutamate Transmembrane Transporter Activity High-affinity Glutamate Transmembrane Transporter Activity Protein Binding Glutamate:sodium Symporter Activity Metal Ion Binding
	Biological Process	Biological_process	Neurotransmitter Uptake Ion Transport Chemical Synaptic Transmission Glutamate Secretion L-glutamate Transmembrane Transport L-glutamate Import Transepithelial Transport D-aspartate Import Across Plasma Membrane Potassium Ion Transmembrane Transport L-glutamate Import Across Plasma Membrane L-aspartate Import Across Plasma Membrane Transport Across Blood-brain Barrier Chloride Transmembrane Transport
Pathways			Astrocytic Glutamate-Glutamine Uptake And Metabolism Glutamate Neurotransmitter Release Cycle Transport of inorganic cations/anions and amino acids/oligopeptides Defective SLC1A3 causes episodic ataxia 6 (EA6)
Drugs			Glutamic acid
Diseases			Episodic ataxias
GWAS		Glomerular filtration rate ( 24351856)	Depression in smokers ( 30219690) Heel bone mineral density ( 30598549 28869591) Intraocular pressure ( 29617998) Lumbar spine bone mineral density (integral) ( 27476799) Lumbar spine bone mineral density (trabecular) ( 27476799) Malaria ( 31844061)
Interacting Genes		61 interacting genes: AQP6 ARL13B BCL2L13 BEST2 CD40 CD53 CD79A CLDN5 CLDN7 CLN8 CREB3L1 CYB561 CYBC1 ELOVL4 ERGIC3 FAM209A GAD2 GJA1 GJA8 GJB5 GORAB GPR152 GPX8 HSD17B11 IER3IP1 IL3RA JAGN1 KCNK5 LEUTX LHFPL2 LHFPL5 LMNA MAPK8IP2 MFF MFSD5 MRPS18B MTERF1 MTIF3 MUC1 REEP4 RETREG3 SCN3B SEC11C SHISAL1 SLC10A6 SLC18A1 SLC1A3 SLC26A6 SLC34A2 SLC7A14 SSMEM1 STX1A TMEM106A TMEM237 TMEM45B TMEM52B TMEM80 TMPRSS2 TMX2 ZDHHC15 ZFYVE27	6 interacting genes: BTN2A2 MGST3 SGK1 TMEM120B TMEM128 ZDHHC17
Entrez ID		85013	6507
HPRD ID		17483	02523
Ensembl ID		ENSG00000132406	ENSG00000079215
Uniprot IDs		B7Z3K1 Q5BJH2	A0A024R050 A0A087WT87 A0A087X0U3 B4DF14 P43003 Q7Z5T0 Q8N169
PDB IDs			5LLM 5LLU 5LM4 5MJU
Enriched GO Terms of Interacting Partners?
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