PPP1R16A and HLA-E

Data Source:
HPRD (two hybrid)

		PPP1R16A	HLA-E
Description		protein phosphatase 1 regulatory subunit 16A	major histocompatibility complex, class I, E
Image		No pdb structure
GO Annotations	Cellular Component	Plasma Membrane	Golgi Membrane Extracellular Space Plasma Membrane External Side Of Plasma Membrane Cell Surface ER To Golgi Transport Vesicle Membrane Phagocytic Vesicle Membrane Early Endosome Membrane MHC Class Ib Protein Complex MHC Class I Protein Complex Recycling Endosome Membrane Extracellular Exosome Integral Component Of Lumenal Side Of Endoplasmic Reticulum Membrane
	Molecular Function	Protein Binding Protein Phosphatase 1 Binding Myosin Phosphatase Regulator Activity Protein Phosphatase Regulator Activity	Signaling Receptor Binding Protein Binding Beta-2-microglobulin Binding MHC Class I Protein Binding Peptide Antigen Binding T Cell Receptor Binding Natural Killer Cell Lectin-like Receptor Binding
	Biological Process	Regulation Of Protein Dephosphorylation Regulation Of Phosphoprotein Phosphatase Activity	Positive Regulation Of Antibody-dependent Cellular Cytotoxicity Positive Regulation Of T Cell Mediated Cytotoxicity Adaptive Immune Response Antigen Processing And Presentation Of Peptide Antigen Via MHC Class I Antigen Processing And Presentation Of Endogenous Peptide Antigen Via MHC Class Ib Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class Ib Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class I, TAP-dependent Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class I, TAP-independent Antigen Processing And Presentation Of Endogenous Peptide Antigen Via MHC Class I Via ER Pathway, TAP-independent Natural Killer Cell Tolerance Induction Positive Regulation Of Immunoglobulin Production Regulation Of Natural Killer Cell Mediated Immunity Positive Regulation Of Natural Killer Cell Mediated Immunity Positive Regulation Of Natural Killer Cell Cytokine Production Immune Response Viral Process Antibacterial Humoral Response Positive Regulation Of Interleukin-13 Production Positive Regulation Of Interleukin-4 Production Positive Regulation Of TRAIL Production Positive Regulation Of Tumor Necrosis Factor Production Positive Regulation Of Natural Killer Cell Proliferation CD8-positive, Alpha-beta T Cell Activation Protection From Natural Killer Cell Mediated Cytotoxicity Innate Immune Response Negative Regulation Of Natural Killer Cell Mediated Cytotoxicity Positive Regulation Of Natural Killer Cell Mediated Cytotoxicity Regulation Of Immune Response Defense Response To Gram-positive Bacterium Interferon-gamma-mediated Signaling Pathway Type I Interferon Signaling Pathway Positive Regulation Of CD8-positive, Alpha-beta T Cell Proliferation Positive Regulation Of CD8-positive, Alpha-beta T Cell Activation
Pathways			ER-Phagosome pathway ER-Phagosome pathway Endosomal/Vacuolar pathway Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell DAP12 interactions DAP12 signaling DAP12 signaling Interferon gamma signaling Interferon alpha/beta signaling Antigen Presentation: Folding, assembly and peptide loading of class I MHC Antigen Presentation: Folding, assembly and peptide loading of class I MHC
Drugs
Diseases
GWAS		Age at first birth ( 27798627) Blood metabolite levels ( 26401656) Educational attainment ( 25201988) Height ( 28552196) Mean corpuscular hemoglobin concentration ( 32888494 27863252)	Autism spectrum disorder or schizophrenia ( 28540026) Hemoglobin levels ( 32327693) Lung cancer ( 28604730) Lung cancer in ever smokers ( 28604730) Neuroticism ( 29255261) Plateletcrit ( 32888494) Red blood cell count ( 32888494) Rosacea symptom severity ( 29771307) Sarcoidosis (Lofgren's syndrome vs non-Lofgren's syndrome) ( 26651848) Small cell lung carcinoma ( 28604730) Squamous cell lung carcinoma ( 28604730)
Interacting Genes		52 interacting genes: ANTKMT ATP23 ATXN7L2 AVPI1 BATF2 C1orf216 C3orf36 CCDC116 CDCA7L CDH24 CKMT1A CKMT1B DDX27 FSD1 HDAC7 HGS HLA-E IDO1 IL16 KAT5 KRTAP19-5 LY6H LZTS2 MCCD1 MRPL12 MYOM1 NDUFAB1 NEK6 NUTF2 PAPSS1 PBDC1 PHPT1 PPP1CA PPP1CB PPP1CC PRKAB2 PRPF31 PUF60 RFLNB RGMA SCNM1 SUV39H1 TFIP11 TLE5 TPP2 TRIP6 TSSK3 TTC23 TXNRD1 UNKL ZFYVE26 ZNF414	9 interacting genes: B2M CALR CD8A F2RL1 KLRC1 KLRC2 KLRD1 PPP1R16A TRAPPC2
Entrez ID		84988	3133
HPRD ID		16454	00877
Ensembl ID		ENSG00000160972	ENSG00000204592
Uniprot IDs		Q96I34	A0A4E9D3W4 A8K8M6 O19682 P13747
PDB IDs			1KPR 1KTL 1MHE 2ESV 3AM8 3BZE 3BZF 3CDG 3CII 5W1V 5W1W 6GGM 6GH1 6GH4 6GHN 6GL1
Enriched GO Terms of Interacting Partners?
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