ORAI1 and TRPC6

Data Source:
HPRD (in vivo, in vitro)

		ORAI1	TRPC6
Description		ORAI calcium release-activated calcium modulator 1	transient receptor potential cation channel subfamily C member 6
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GO Annotations	Cellular Component	Cytosol Plasma Membrane Integral Component Of Plasma Membrane Membrane Basolateral Plasma Membrane Calcium Channel Complex Plasma Membrane Raft Membrane Raft	Cytoplasm Plasma Membrane Integral Component Of Plasma Membrane Membrane Cation Channel Complex Slit Diaphragm
	Molecular Function	Calcium Channel Activity Protein Binding Calmodulin Binding Store-operated Calcium Channel Activity Identical Protein Binding	Actin Binding Cation Channel Activity Protein Binding Store-operated Calcium Channel Activity Clathrin Binding Protein Homodimerization Activity Actinin Binding ATPase Binding Inositol 1,4,5 Trisphosphate Binding
	Biological Process	Store-operated Calcium Entry Adaptive Immune Response Positive Regulation Of Adenylate Cyclase Activity Regulation Of Calcium Ion Transport Positive Regulation Of Calcium Ion Transport Mammary Gland Epithelium Development Calcium Ion Import Calcium Ion Transmembrane Transport	Cation Transport Manganese Ion Transport Positive Regulation Of Cytosolic Calcium Ion Concentration Single Fertilization Aging Positive Regulation Of Peptidyl-threonine Phosphorylation Platelet Activation Neuron Differentiation Positive Regulation Of Ion Transmembrane Transporter Activity Positive Regulation Of Neuron Differentiation Negative Regulation Of Dendrite Morphogenesis Regulation Of Cytosolic Calcium Ion Concentration Positive Regulation Of Calcium Ion Transport Cellular Response To Hydrogen Peroxide Calcium Ion Transmembrane Transport Cellular Response To Hypoxia
Pathways		Elevation of cytosolic Ca2+ levels Ion homeostasis Antigen activates B Cell Receptor (BCR) leading to generation of second messengers	Effects of PIP2 hydrolysis Elevation of cytosolic Ca2+ levels TRP channels Role of second messengers in netrin-1 signaling
Drugs
Diseases			Nephrotic syndrome and focal segmental glomerulosclerosis
GWAS		Experiencing mood swings ( 29500382) Major depressive disorder ( 27777418)	Change in LVEF in response to paclitaxel and trastuzumab in HER2+ breast cancer ( 28763429) General risk tolerance (MTAG) ( 30643258) Lung adenocarcinoma ( 28604730) Menarche (age at onset) ( 25231870) Plateletcrit ( 32888494) Severity of nausea and vomiting of pregnancy ( 29563502) White blood cell count ( 32888494)
Interacting Genes		2 interacting genes: TRPC3 TRPC6	9 interacting genes: FYN ITPR3 MX1 ORAI1 RNF24 SRC TRPC3 TRPC7 TRPM2
Entrez ID		84876	7225
HPRD ID		08599	04710
Ensembl ID			ENSG00000137672
Uniprot IDs		A0A024RBT3 Q96D31	Q9Y210
PDB IDs		2MAK 4EHQ	5YX9 6UZ8 6UZA 7A6U
Enriched GO Terms of Interacting Partners?
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